Musical aptitude is associated with AVPR1A-haplotypes.

Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and...

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Autores principales:	Liisa T Ukkola, Päivi Onkamo, Pirre Raijas, Kai Karma, Irma Järvelä
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a142e453b2f747f69cf3c23c3f88c51d
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spelling	oai:doaj.org-article:a142e453b2f747f69cf3c23c3f88c51d2021-11-25T06:22:34ZMusical aptitude is associated with AVPR1A-haplotypes.1932-620310.1371/journal.pone.0005534https://doaj.org/article/a142e453b2f747f69cf3c23c3f88c51d2009-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19461995/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and even creativity in music. In order to understand the neurobiological basis of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1A (AVPR1A), serotonin transporter (SLC6A4), catecol-O-methyltranferase (COMT), dopamin receptor D2 (DRD2) and tyrosine hydroxylase 1 (TPH1), genes associated with social bonding and cognitive functions in 19 Finnish families (n = 343 members) with professional musicians and/or active amateurs. All family members were tested for musical aptitude using the auditory structuring ability test (Karma Music test; KMT) and Carl Seashores tests for pitch (SP) and for time (ST). Data on creativity in music (composing, improvising and/or arranging music) was surveyed using a web-based questionnaire. Here we show for the first time that creative functions in music have a strong genetic component (h(2) = .84; composing h(2) = .40; arranging h(2) = .46; improvising h(2) = .62) in Finnish multigenerational families. We also show that high music test scores are significantly associated with creative functions in music (p<.0001). We discovered an overall haplotype association with AVPR1A gene (markers RS1 and RS3) and KMT (p = 0.0008; corrected p = 0.00002), SP (p = 0.0261; corrected p = 0.0072) and combined music test scores (COMB) (p = 0.0056; corrected p = 0.0006). AVPR1A haplotype AVR+RS1 further suggested a positive association with ST (p = 0.0038; corrected p = 0.00184) and COMB (p = 0.0083; corrected p = 0.0040) using haplotype-based association test HBAT. The results suggest that the neurobiology of music perception and production is likely to be related to the pathways affecting intrinsic attachment behavior.Liisa T UkkolaPäivi OnkamoPirre RaijasKai KarmaIrma JärveläPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 5, p e5534 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liisa T Ukkola Päivi Onkamo Pirre Raijas Kai Karma Irma Järvelä Musical aptitude is associated with AVPR1A-haplotypes.
description	Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and even creativity in music. In order to understand the neurobiological basis of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1A (AVPR1A), serotonin transporter (SLC6A4), catecol-O-methyltranferase (COMT), dopamin receptor D2 (DRD2) and tyrosine hydroxylase 1 (TPH1), genes associated with social bonding and cognitive functions in 19 Finnish families (n = 343 members) with professional musicians and/or active amateurs. All family members were tested for musical aptitude using the auditory structuring ability test (Karma Music test; KMT) and Carl Seashores tests for pitch (SP) and for time (ST). Data on creativity in music (composing, improvising and/or arranging music) was surveyed using a web-based questionnaire. Here we show for the first time that creative functions in music have a strong genetic component (h(2) = .84; composing h(2) = .40; arranging h(2) = .46; improvising h(2) = .62) in Finnish multigenerational families. We also show that high music test scores are significantly associated with creative functions in music (p<.0001). We discovered an overall haplotype association with AVPR1A gene (markers RS1 and RS3) and KMT (p = 0.0008; corrected p = 0.00002), SP (p = 0.0261; corrected p = 0.0072) and combined music test scores (COMB) (p = 0.0056; corrected p = 0.0006). AVPR1A haplotype AVR+RS1 further suggested a positive association with ST (p = 0.0038; corrected p = 0.00184) and COMB (p = 0.0083; corrected p = 0.0040) using haplotype-based association test HBAT. The results suggest that the neurobiology of music perception and production is likely to be related to the pathways affecting intrinsic attachment behavior.
format	article
author	Liisa T Ukkola Päivi Onkamo Pirre Raijas Kai Karma Irma Järvelä
author_facet	Liisa T Ukkola Päivi Onkamo Pirre Raijas Kai Karma Irma Järvelä
author_sort	Liisa T Ukkola
title	Musical aptitude is associated with AVPR1A-haplotypes.
title_short	Musical aptitude is associated with AVPR1A-haplotypes.
title_full	Musical aptitude is associated with AVPR1A-haplotypes.
title_fullStr	Musical aptitude is associated with AVPR1A-haplotypes.
title_full_unstemmed	Musical aptitude is associated with AVPR1A-haplotypes.
title_sort	musical aptitude is associated with avpr1a-haplotypes.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/a142e453b2f747f69cf3c23c3f88c51d
work_keys_str_mv	AT liisatukkola musicalaptitudeisassociatedwithavpr1ahaplotypes AT paivionkamo musicalaptitudeisassociatedwithavpr1ahaplotypes AT pirreraijas musicalaptitudeisassociatedwithavpr1ahaplotypes AT kaikarma musicalaptitudeisassociatedwithavpr1ahaplotypes AT irmajarvela musicalaptitudeisassociatedwithavpr1ahaplotypes
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Musical aptitude is associated with AVPR1A-haplotypes.

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