Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration

Abstract Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyse...

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Autores principales:	Hiromasa Hirai, Mariko Yamashita, Masanori Matsumoto, Masaki Hayakawa, Kazuya Sakai, Tetsuo Ueda, Nahoko Ogata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a143249937484e65b9754063046a981d
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spelling	oai:doaj.org-article:a143249937484e65b9754063046a981d2021-12-02T18:01:41ZAnalysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration10.1038/s41598-021-99557-62045-2322https://doaj.org/article/a143249937484e65b9754063046a981d2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99557-6https://doaj.org/toc/2045-2322Abstract Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.Hiromasa HiraiMariko YamashitaMasanori MatsumotoMasaki HayakawaKazuya SakaiTetsuo UedaNahoko OgataNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiromasa Hirai Mariko Yamashita Masanori Matsumoto Masaki Hayakawa Kazuya Sakai Tetsuo Ueda Nahoko Ogata Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
description	Abstract Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.
format	article
author	Hiromasa Hirai Mariko Yamashita Masanori Matsumoto Masaki Hayakawa Kazuya Sakai Tetsuo Ueda Nahoko Ogata
author_facet	Hiromasa Hirai Mariko Yamashita Masanori Matsumoto Masaki Hayakawa Kazuya Sakai Tetsuo Ueda Nahoko Ogata
author_sort	Hiromasa Hirai
title	Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_short	Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_full	Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_fullStr	Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_full_unstemmed	Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
title_sort	analysis focusing on plasma von willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a143249937484e65b9754063046a981d
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Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration

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