COVID-19 Hyperinflammation: What about Neutrophils?

ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated. Here, a gene network approach was used on recently published data sets to identify possib...

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Autor principal:	Athanasios Didangelos
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	COVID-19 SARS-CoV-2 coronavirus inflammation neutrophil Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a14704637f2e4b9eb6062e91fe24266f
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spelling	oai:doaj.org-article:a14704637f2e4b9eb6062e91fe24266f2021-11-15T15:30:14ZCOVID-19 Hyperinflammation: What about Neutrophils?10.1128/mSphere.00367-202379-5042https://doaj.org/article/a14704637f2e4b9eb6062e91fe24266f2020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00367-20https://doaj.org/toc/2379-5042ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated. Here, a gene network approach was used on recently published data sets to identify possible COVID-19 inflammatory mechanisms and bioactive genes. First, network analysis of putative SARS-CoV-2 cellular receptors led to the mining of a neutrophil-response signature and relevant inflammatory genes. Second, analysis of RNA-seq data sets of lung cells infected with SARS-CoV-2 revealed that infected cells expressed neutrophil-attracting chemokines. Third, analysis of RNA-seq data sets of bronchoalveolar lavage fluid cells from COVID-19 patients identified upregulation of neutrophil genes and chemokines. Different inflammatory genes mined here, including TNFR, IL-8, CXCR1, CXCR2, ADAM10, GPR84, MME, ANPEP, and LAP3, might be druggable targets in efforts to limit SARS-CoV-2 inflammation in severe clinical cases. The possible role of neutrophils in COVID-19 inflammation needs to be studied further.Athanasios DidangelosAmerican Society for MicrobiologyarticleCOVID-19SARS-CoV-2coronavirusinflammationneutrophilMicrobiologyQR1-502ENmSphere, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 coronavirus inflammation neutrophil Microbiology QR1-502
spellingShingle	COVID-19 SARS-CoV-2 coronavirus inflammation neutrophil Microbiology QR1-502 Athanasios Didangelos COVID-19 Hyperinflammation: What about Neutrophils?
description	ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated. Here, a gene network approach was used on recently published data sets to identify possible COVID-19 inflammatory mechanisms and bioactive genes. First, network analysis of putative SARS-CoV-2 cellular receptors led to the mining of a neutrophil-response signature and relevant inflammatory genes. Second, analysis of RNA-seq data sets of lung cells infected with SARS-CoV-2 revealed that infected cells expressed neutrophil-attracting chemokines. Third, analysis of RNA-seq data sets of bronchoalveolar lavage fluid cells from COVID-19 patients identified upregulation of neutrophil genes and chemokines. Different inflammatory genes mined here, including TNFR, IL-8, CXCR1, CXCR2, ADAM10, GPR84, MME, ANPEP, and LAP3, might be druggable targets in efforts to limit SARS-CoV-2 inflammation in severe clinical cases. The possible role of neutrophils in COVID-19 inflammation needs to be studied further.
format	article
author	Athanasios Didangelos
author_facet	Athanasios Didangelos
author_sort	Athanasios Didangelos
title	COVID-19 Hyperinflammation: What about Neutrophils?
title_short	COVID-19 Hyperinflammation: What about Neutrophils?
title_full	COVID-19 Hyperinflammation: What about Neutrophils?
title_fullStr	COVID-19 Hyperinflammation: What about Neutrophils?
title_full_unstemmed	COVID-19 Hyperinflammation: What about Neutrophils?
title_sort	covid-19 hyperinflammation: what about neutrophils?
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/a14704637f2e4b9eb6062e91fe24266f
work_keys_str_mv	AT athanasiosdidangelos covid19hyperinflammationwhataboutneutrophils
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COVID-19 Hyperinflammation: What about Neutrophils?

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