Early bradycardia detection and therapeutic interventions in preterm infant monitoring

Abstract In very preterm infants, cardio-respiratory events and associated hypoxemia occurring during early postnatal life have been associated with risks of retinopathy, growth alteration and neurodevelopment impairment. These events are commonly detected by continuous cardio-respiratory monitoring...

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Autores principales:	Matthieu Doyen, Alfredo I. Hernández, Cyril Flamant, Antoine Defontaine, Géraldine Favrais, Miguel Altuve, Bruno Laviolle, Alain Beuchée, Guy Carrault, Patrick Pladys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a14b90aadd794bedb7543c0c5f63d601
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spelling	oai:doaj.org-article:a14b90aadd794bedb7543c0c5f63d6012021-12-02T15:53:01ZEarly bradycardia detection and therapeutic interventions in preterm infant monitoring10.1038/s41598-021-89468-x2045-2322https://doaj.org/article/a14b90aadd794bedb7543c0c5f63d6012021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89468-xhttps://doaj.org/toc/2045-2322Abstract In very preterm infants, cardio-respiratory events and associated hypoxemia occurring during early postnatal life have been associated with risks of retinopathy, growth alteration and neurodevelopment impairment. These events are commonly detected by continuous cardio-respiratory monitoring in neonatal intensive care units (NICU), through the associated bradycardia. NICU nurse interventions are mainly triggered by these alarms. In this work, we acquired data from 52 preterm infants during NICU monitoring, in order to propose an early bradycardia detector which is based on a decentralized fusion of three detectors. The main objective is to improve automatic detection under real-life conditions without altering performance with respect to that of a monitor commonly used in NICU. We used heart rate lower than 80 bpm during at least 10 sec to define bradycardia. With this definition we observed a high rate of false alarms (64%) in real-life and that 29% of the relevant alarms were not followed by manual interventions. Concerning the proposed detection method, when compared to current monitors, it provided a significant decrease of the detection delay of 2.9 seconds, without alteration of the sensitivity (97.6% vs 95.2%) and false alarm rate (63.7% vs 64.1%). We expect that such an early detection will improve the response of the newborn to the intervention and allow for the development of new automatic therapeutic strategies which could complement manual intervention and decrease the sepsis risk.Matthieu DoyenAlfredo I. HernándezCyril FlamantAntoine DefontaineGéraldine FavraisMiguel AltuveBruno LaviolleAlain BeuchéeGuy CarraultPatrick PladysNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthieu Doyen Alfredo I. Hernández Cyril Flamant Antoine Defontaine Géraldine Favrais Miguel Altuve Bruno Laviolle Alain Beuchée Guy Carrault Patrick Pladys Early bradycardia detection and therapeutic interventions in preterm infant monitoring
description	Abstract In very preterm infants, cardio-respiratory events and associated hypoxemia occurring during early postnatal life have been associated with risks of retinopathy, growth alteration and neurodevelopment impairment. These events are commonly detected by continuous cardio-respiratory monitoring in neonatal intensive care units (NICU), through the associated bradycardia. NICU nurse interventions are mainly triggered by these alarms. In this work, we acquired data from 52 preterm infants during NICU monitoring, in order to propose an early bradycardia detector which is based on a decentralized fusion of three detectors. The main objective is to improve automatic detection under real-life conditions without altering performance with respect to that of a monitor commonly used in NICU. We used heart rate lower than 80 bpm during at least 10 sec to define bradycardia. With this definition we observed a high rate of false alarms (64%) in real-life and that 29% of the relevant alarms were not followed by manual interventions. Concerning the proposed detection method, when compared to current monitors, it provided a significant decrease of the detection delay of 2.9 seconds, without alteration of the sensitivity (97.6% vs 95.2%) and false alarm rate (63.7% vs 64.1%). We expect that such an early detection will improve the response of the newborn to the intervention and allow for the development of new automatic therapeutic strategies which could complement manual intervention and decrease the sepsis risk.
format	article
author	Matthieu Doyen Alfredo I. Hernández Cyril Flamant Antoine Defontaine Géraldine Favrais Miguel Altuve Bruno Laviolle Alain Beuchée Guy Carrault Patrick Pladys
author_facet	Matthieu Doyen Alfredo I. Hernández Cyril Flamant Antoine Defontaine Géraldine Favrais Miguel Altuve Bruno Laviolle Alain Beuchée Guy Carrault Patrick Pladys
author_sort	Matthieu Doyen
title	Early bradycardia detection and therapeutic interventions in preterm infant monitoring
title_short	Early bradycardia detection and therapeutic interventions in preterm infant monitoring
title_full	Early bradycardia detection and therapeutic interventions in preterm infant monitoring
title_fullStr	Early bradycardia detection and therapeutic interventions in preterm infant monitoring
title_full_unstemmed	Early bradycardia detection and therapeutic interventions in preterm infant monitoring
title_sort	early bradycardia detection and therapeutic interventions in preterm infant monitoring
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a14b90aadd794bedb7543c0c5f63d601
work_keys_str_mv	AT matthieudoyen earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT alfredoihernandez earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT cyrilflamant earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT antoinedefontaine earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT geraldinefavrais earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT miguelaltuve earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT brunolaviolle earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT alainbeuchee earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT guycarrault earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring AT patrickpladys earlybradycardiadetectionandtherapeuticinterventionsinpreterminfantmonitoring
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Early bradycardia detection and therapeutic interventions in preterm infant monitoring

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