Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells

The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the tran...

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Autores principales:	Chiara Cencioni, Francesco Spallotta, Matteo Savoia, Carsten Kuenne, Stefan Guenther, Agnese Re, Susanne Wingert, Maike Rehage, Duran Sürün, Mauro Siragusa, Jacob G. Smith, Frank Schnütgen, Harald von Melchner, Michael A. Rieger, Fabio Martelli, Antonella Riccio, Ingrid Fleming, Thomas Braun, Andreas M. Zeiher, Antonella Farsetti, Carlo Gaetano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a14bcea599a241e4b7bb31b5f8b2ac2b
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spelling	oai:doaj.org-article:a14bcea599a241e4b7bb31b5f8b2ac2b2021-12-02T16:49:30ZZeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells10.1038/s41467-018-03668-02041-1723https://doaj.org/article/a14bcea599a241e4b7bb31b5f8b2ac2b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03668-0https://doaj.org/toc/2041-1723The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the transcriptional repressor Zeb1.Chiara CencioniFrancesco SpallottaMatteo SavoiaCarsten KuenneStefan GuentherAgnese ReSusanne WingertMaike RehageDuran SürünMauro SiragusaJacob G. SmithFrank SchnütgenHarald von MelchnerMichael A. RiegerFabio MartelliAntonella RiccioIngrid FlemingThomas BraunAndreas M. ZeiherAntonella FarsettiCarlo GaetanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Cencioni Francesco Spallotta Matteo Savoia Carsten Kuenne Stefan Guenther Agnese Re Susanne Wingert Maike Rehage Duran Sürün Mauro Siragusa Jacob G. Smith Frank Schnütgen Harald von Melchner Michael A. Rieger Fabio Martelli Antonella Riccio Ingrid Fleming Thomas Braun Andreas M. Zeiher Antonella Farsetti Carlo Gaetano Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
description	The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the transcriptional repressor Zeb1.
format	article
author	Chiara Cencioni Francesco Spallotta Matteo Savoia Carsten Kuenne Stefan Guenther Agnese Re Susanne Wingert Maike Rehage Duran Sürün Mauro Siragusa Jacob G. Smith Frank Schnütgen Harald von Melchner Michael A. Rieger Fabio Martelli Antonella Riccio Ingrid Fleming Thomas Braun Andreas M. Zeiher Antonella Farsetti Carlo Gaetano
author_facet	Chiara Cencioni Francesco Spallotta Matteo Savoia Carsten Kuenne Stefan Guenther Agnese Re Susanne Wingert Maike Rehage Duran Sürün Mauro Siragusa Jacob G. Smith Frank Schnütgen Harald von Melchner Michael A. Rieger Fabio Martelli Antonella Riccio Ingrid Fleming Thomas Braun Andreas M. Zeiher Antonella Farsetti Carlo Gaetano
author_sort	Chiara Cencioni
title	Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
title_short	Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
title_full	Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
title_fullStr	Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
title_full_unstemmed	Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
title_sort	zeb1-hdac2-enos circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a14bcea599a241e4b7bb31b5f8b2ac2b
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Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells

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