Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.

<h4>Background</h4>Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand break...

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Autores principales: Bing Xu, Zhaoliang Sun, Zhaojian Liu, Haiyang Guo, Qiao Liu, Haiyan Jiang, Yongxin Zou, Yaoqin Gong, Jay A Tischfield, Changshun Shao
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/a14cc6b58dd34a4cb19fe6d1772f6650
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