Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury

Background: Repetitive strain injuries caused by repetitive occupational work are difficult to prevent for multiple reasons. Therefore, we examined the effectiveness of manual therapy (MT) with rest to treat the inflammation and fibrosis that develops through the performance of a repetitive task. We...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mary F. Barbe, Siva Tejaa Panibatla, Michele Y. Harris, Mamta Amin, Jocelynne T. Dorotan, Geneva E. Cruz, Geoffrey M. Bove
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	overuse injury work-related musculoskeletal disorders massage therapy repetitive motion disorder fibrosis neuropathy Physiology QP1-981
Acceso en línea:	https://doaj.org/article/a14dd9d2603d4561a4b05996edd5aaea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a14dd9d2603d4561a4b05996edd5aaea
record_format	dspace
spelling	oai:doaj.org-article:a14dd9d2603d4561a4b05996edd5aaea2021-11-04T07:37:45ZManual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury1664-042X10.3389/fphys.2021.755923https://doaj.org/article/a14dd9d2603d4561a4b05996edd5aaea2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.755923/fullhttps://doaj.org/toc/1664-042XBackground: Repetitive strain injuries caused by repetitive occupational work are difficult to prevent for multiple reasons. Therefore, we examined the effectiveness of manual therapy (MT) with rest to treat the inflammation and fibrosis that develops through the performance of a repetitive task. We hypothesized that this treatment would reduce task-induced sensorimotor declines and neuromuscular inflammation.Methods: Twenty-nine female Sprague-Dawley rats performed a reaching and lever-pulling task for 14weeks. All ceased performing the task at 14weeks. Ten were euthanized at this timepoint (TASK). Nine received manual therapy to their upper extremities while resting 7weeks (MTR); 10 were assigned to rest alone (REST). Ten additional food restricted rats were included that neither performed the task nor received manual therapy (FRC).Results: Confirming previous experiments, TASK rats showed behavioral changes (forepaw mechanical hypersensitivity, reduced grip strength, lowered forelimb/forepaw agility, and noxious cold temperature sensitivity), reduced median nerve conduction velocity (NCV), and pathological tissue changes (myelin degradation, increased median nerve and muscle inflammation, and collagen production). Manual therapy with rest (MTR) ameliorated cold sensitivity seen in REST rats, enhanced muscle interleukin 10 (IL-10) more than in REST rats, lead to improvement in most other measures, compared to TASK rats. REST rats showed improved grip strength, lowered nerve inflammation and degraded myelin, and lowered muscle tumor necrosis factor alpha (TNFα) and collagen I levels, compared to TASK rats, yet maintained lowered forelimb/forepaw agility and NCV, and increased neural fibrosis.Conclusion: In our model of repetitive motion disorder, manual therapy during rest had modest effects on behavioral, histological, and physiological measures, compared to rest alone. These findings stand in contrast to the robust preventive effects of manual therapy in this same model.Mary F. BarbeSiva Tejaa PanibatlaMichele Y. HarrisMamta AminJocelynne T. DorotanGeneva E. CruzGeoffrey M. BoveGeoffrey M. BoveFrontiers Media S.A.articleoveruse injurywork-related musculoskeletal disordersmassage therapyrepetitive motion disorderfibrosisneuropathyPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	overuse injury work-related musculoskeletal disorders massage therapy repetitive motion disorder fibrosis neuropathy Physiology QP1-981
spellingShingle	overuse injury work-related musculoskeletal disorders massage therapy repetitive motion disorder fibrosis neuropathy Physiology QP1-981 Mary F. Barbe Siva Tejaa Panibatla Michele Y. Harris Mamta Amin Jocelynne T. Dorotan Geneva E. Cruz Geoffrey M. Bove Geoffrey M. Bove Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
description	Background: Repetitive strain injuries caused by repetitive occupational work are difficult to prevent for multiple reasons. Therefore, we examined the effectiveness of manual therapy (MT) with rest to treat the inflammation and fibrosis that develops through the performance of a repetitive task. We hypothesized that this treatment would reduce task-induced sensorimotor declines and neuromuscular inflammation.Methods: Twenty-nine female Sprague-Dawley rats performed a reaching and lever-pulling task for 14weeks. All ceased performing the task at 14weeks. Ten were euthanized at this timepoint (TASK). Nine received manual therapy to their upper extremities while resting 7weeks (MTR); 10 were assigned to rest alone (REST). Ten additional food restricted rats were included that neither performed the task nor received manual therapy (FRC).Results: Confirming previous experiments, TASK rats showed behavioral changes (forepaw mechanical hypersensitivity, reduced grip strength, lowered forelimb/forepaw agility, and noxious cold temperature sensitivity), reduced median nerve conduction velocity (NCV), and pathological tissue changes (myelin degradation, increased median nerve and muscle inflammation, and collagen production). Manual therapy with rest (MTR) ameliorated cold sensitivity seen in REST rats, enhanced muscle interleukin 10 (IL-10) more than in REST rats, lead to improvement in most other measures, compared to TASK rats. REST rats showed improved grip strength, lowered nerve inflammation and degraded myelin, and lowered muscle tumor necrosis factor alpha (TNFα) and collagen I levels, compared to TASK rats, yet maintained lowered forelimb/forepaw agility and NCV, and increased neural fibrosis.Conclusion: In our model of repetitive motion disorder, manual therapy during rest had modest effects on behavioral, histological, and physiological measures, compared to rest alone. These findings stand in contrast to the robust preventive effects of manual therapy in this same model.
format	article
author	Mary F. Barbe Siva Tejaa Panibatla Michele Y. Harris Mamta Amin Jocelynne T. Dorotan Geneva E. Cruz Geoffrey M. Bove Geoffrey M. Bove
author_facet	Mary F. Barbe Siva Tejaa Panibatla Michele Y. Harris Mamta Amin Jocelynne T. Dorotan Geneva E. Cruz Geoffrey M. Bove Geoffrey M. Bove
author_sort	Mary F. Barbe
title	Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
title_short	Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
title_full	Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
title_fullStr	Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
title_full_unstemmed	Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury
title_sort	manual therapy with rest as a treatment for established inflammation and fibrosis in a rat model of repetitive strain injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a14dd9d2603d4561a4b05996edd5aaea
work_keys_str_mv	AT maryfbarbe manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT sivatejaapanibatla manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT micheleyharris manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT mamtaamin manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT jocelynnetdorotan manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT genevaecruz manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT geoffreymbove manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury AT geoffreymbove manualtherapywithrestasatreatmentforestablishedinflammationandfibrosisinaratmodelofrepetitivestraininjury
_version_	1718445041118085120

Manual Therapy With Rest as a Treatment for Established Inflammation and Fibrosis in a Rat Model of Repetitive Strain Injury

Ejemplares similares