LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.

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Autores principales: Pingping Zhu, Yanying Wang, Jiayi Wu, Guanling Huang, Benyu Liu, Buqing Ye, Ying Du, Guangxia Gao, Yong Tian, Lei He, Zusen Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/a14e02b6cfc44b4dbfedd36546c25516
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spelling oai:doaj.org-article:a14e02b6cfc44b4dbfedd36546c255162021-12-02T17:31:18ZLncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells10.1038/ncomms136082041-1723https://doaj.org/article/a14e02b6cfc44b4dbfedd36546c255162016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13608https://doaj.org/toc/2041-1723Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.Pingping ZhuYanying WangJiayi WuGuanling HuangBenyu LiuBuqing YeYing DuGuangxia GaoYong TianLei HeZusen FanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pingping Zhu
Yanying Wang
Jiayi Wu
Guanling Huang
Benyu Liu
Buqing Ye
Ying Du
Guangxia Gao
Yong Tian
Lei He
Zusen Fan
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
description Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.
format article
author Pingping Zhu
Yanying Wang
Jiayi Wu
Guanling Huang
Benyu Liu
Buqing Ye
Ying Du
Guangxia Gao
Yong Tian
Lei He
Zusen Fan
author_facet Pingping Zhu
Yanying Wang
Jiayi Wu
Guanling Huang
Benyu Liu
Buqing Ye
Ying Du
Guangxia Gao
Yong Tian
Lei He
Zusen Fan
author_sort Pingping Zhu
title LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
title_short LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
title_full LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
title_fullStr LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
title_full_unstemmed LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
title_sort lncbrm initiates yap1 signalling activation to drive self-renewal of liver cancer stem cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/a14e02b6cfc44b4dbfedd36546c25516
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AT yanyingwang lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT jiayiwu lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT guanlinghuang lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT benyuliu lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT buqingye lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT yingdu lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT guangxiagao lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT yongtian lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT leihe lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
AT zusenfan lncbrminitiatesyap1signallingactivationtodriveselfrenewaloflivercancerstemcells
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