Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells

PIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN.

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Auteurs principaux:	Satomi Matsuoka, Masahiro Ueda
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a14ed1724f27488b8b3bd9c279edce37
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spelling	oai:doaj.org-article:a14ed1724f27488b8b3bd9c279edce372021-12-02T17:33:05ZMutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells10.1038/s41467-018-06856-02041-1723https://doaj.org/article/a14ed1724f27488b8b3bd9c279edce372018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06856-0https://doaj.org/toc/2041-1723PIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN.Satomi MatsuokaMasahiro UedaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satomi Matsuoka Masahiro Ueda Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
description	PIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN.
format	article
author	Satomi Matsuoka Masahiro Ueda
author_facet	Satomi Matsuoka Masahiro Ueda
author_sort	Satomi Matsuoka
title	Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
title_short	Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
title_full	Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
title_fullStr	Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
title_full_unstemmed	Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
title_sort	mutual inhibition between pten and pip3 generates bistability for polarity in motile cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a14ed1724f27488b8b3bd9c279edce37
work_keys_str_mv	AT satomimatsuoka mutualinhibitionbetweenptenandpip3generatesbistabilityforpolarityinmotilecells AT masahiroueda mutualinhibitionbetweenptenandpip3generatesbistabilityforpolarityinmotilecells
_version_	1718380078942912512

Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells

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