North African populations carry the signature of admixture with Neandertals.

One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient populat...

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Autores principales:	Federico Sánchez-Quinto, Laura R Botigué, Sergi Civit, Conxita Arenas, María C Avila-Arcos, Carlos D Bustamante, David Comas, Carles Lalueza-Fox
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a155363dfc5548128dada257a2366941
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spelling	oai:doaj.org-article:a155363dfc5548128dada257a23669412021-11-18T08:11:37ZNorth African populations carry the signature of admixture with Neandertals.1932-620310.1371/journal.pone.0047765https://doaj.org/article/a155363dfc5548128dada257a23669412012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082212/?tool=EBIhttps://doaj.org/toc/1932-6203One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.Federico Sánchez-QuintoLaura R BotiguéSergi CivitConxita ArenasMaría C Avila-ArcosCarlos D BustamanteDavid ComasCarles Lalueza-FoxPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47765 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Federico Sánchez-Quinto Laura R Botigué Sergi Civit Conxita Arenas María C Avila-Arcos Carlos D Bustamante David Comas Carles Lalueza-Fox North African populations carry the signature of admixture with Neandertals.
description	One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals.
format	article
author	Federico Sánchez-Quinto Laura R Botigué Sergi Civit Conxita Arenas María C Avila-Arcos Carlos D Bustamante David Comas Carles Lalueza-Fox
author_facet	Federico Sánchez-Quinto Laura R Botigué Sergi Civit Conxita Arenas María C Avila-Arcos Carlos D Bustamante David Comas Carles Lalueza-Fox
author_sort	Federico Sánchez-Quinto
title	North African populations carry the signature of admixture with Neandertals.
title_short	North African populations carry the signature of admixture with Neandertals.
title_full	North African populations carry the signature of admixture with Neandertals.
title_fullStr	North African populations carry the signature of admixture with Neandertals.
title_full_unstemmed	North African populations carry the signature of admixture with Neandertals.
title_sort	north african populations carry the signature of admixture with neandertals.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a155363dfc5548128dada257a2366941
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North African populations carry the signature of admixture with Neandertals.

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