Nanotechnology for treating osteoporotic vertebral fractures
Chunxia Gao,1,* Donglei Wei,1,* Huilin Yang,1 Tao Chen,2 Lei Yang1,3 1Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, 2Robotics and Microsystems Center, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow&...
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Dove Medical Press
2015
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oai:doaj.org-article:a155de7d82214b9d985348e139283f472021-12-02T02:10:33ZNanotechnology for treating osteoporotic vertebral fractures1178-2013https://doaj.org/article/a155de7d82214b9d985348e139283f472015-08-01T00:00:00Zhttp://www.dovepress.com/nanotechnology-for-treating-osteoporotic-vertebral-fractures-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chunxia Gao,1,* Donglei Wei,1,* Huilin Yang,1 Tao Chen,2 Lei Yang1,3 1Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, 2Robotics and Microsystems Center, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 3Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided. Keywords: nanomaterials, osteoporosis, vertebral fracture, kyphoplasty, bone cement, pedicle screw, radiopacifierGao CWei DYang HChen TYang LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 5139-5157 (2015) |
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DOAJ |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Gao C Wei D Yang H Chen T Yang L Nanotechnology for treating osteoporotic vertebral fractures |
| description |
Chunxia Gao,1,* Donglei Wei,1,* Huilin Yang,1 Tao Chen,2 Lei Yang1,3 1Department of Orthopaedic Surgery and Orthopaedic Institute, First Affiliated Hospital, 2Robotics and Microsystems Center, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 3Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided. Keywords: nanomaterials, osteoporosis, vertebral fracture, kyphoplasty, bone cement, pedicle screw, radiopacifier |
| format |
article |
| author |
Gao C Wei D Yang H Chen T Yang L |
| author_facet |
Gao C Wei D Yang H Chen T Yang L |
| author_sort |
Gao C |
| title |
Nanotechnology for treating osteoporotic vertebral fractures |
| title_short |
Nanotechnology for treating osteoporotic vertebral fractures |
| title_full |
Nanotechnology for treating osteoporotic vertebral fractures |
| title_fullStr |
Nanotechnology for treating osteoporotic vertebral fractures |
| title_full_unstemmed |
Nanotechnology for treating osteoporotic vertebral fractures |
| title_sort |
nanotechnology for treating osteoporotic vertebral fractures |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/a155de7d82214b9d985348e139283f47 |
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AT gaoc nanotechnologyfortreatingosteoporoticvertebralfractures AT weid nanotechnologyfortreatingosteoporoticvertebralfractures AT yangh nanotechnologyfortreatingosteoporoticvertebralfractures AT chent nanotechnologyfortreatingosteoporoticvertebralfractures AT yangl nanotechnologyfortreatingosteoporoticvertebralfractures |
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