Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer

Abstract Adipocytes influence breast cancer behaviour via fatty acid release into the tumour microenvironment. Co-culturing human adipocytes and breast cancer cells increased CD36 expression, with fatty acid import into breast cancer cells. Genetic ablation of CD36 attenuates adipocyte-induced epith...

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Autores principales:	Jones Gyamfi, Joo Hye Yeo, Doru Kwon, Byung Soh Min, Yoon Jin Cha, Ja Seung Koo, Joon Jeong, Jinu Lee, Junjeong Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a156fe2efe22458ca29d0ef7df1fc3eb
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spelling	oai:doaj.org-article:a156fe2efe22458ca29d0ef7df1fc3eb2021-12-02T18:14:00ZInteraction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer10.1038/s41523-021-00324-72374-4677https://doaj.org/article/a156fe2efe22458ca29d0ef7df1fc3eb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00324-7https://doaj.org/toc/2374-4677Abstract Adipocytes influence breast cancer behaviour via fatty acid release into the tumour microenvironment. Co-culturing human adipocytes and breast cancer cells increased CD36 expression, with fatty acid import into breast cancer cells. Genetic ablation of CD36 attenuates adipocyte-induced epithelial-mesenchymal transition (EMT) and stemness. We show a feedforward loop between CD36 and STAT3; where CD36 activates STAT3 signalling and STAT3 binds to the CD36 promoter, regulating its expression. CD36 expression results in metabolic reprogramming, with a shift towards fatty acid oxidation. CD36 inhibition induces de novo lipogenesis in breast cancer cells. Increased CD36 expression occurs with increased FABP4 expression. We showed that CD36 directly interacts with FABP4 to regulate fatty acid import, transport, and metabolism. CD36 and FABP4 inhibition induces apoptosis in tumour cells. These results indicate that CD36 mediates fatty acid import from adipocytes into cancer cells and activates signalling pathways that drive tumour progression. Targeting CD36 may have a potential for therapy, which will target the tumour microenvironment.Jones GyamfiJoo Hye YeoDoru KwonByung Soh MinYoon Jin ChaJa Seung KooJoon JeongJinu LeeJunjeong ChoiNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jones Gyamfi Joo Hye Yeo Doru Kwon Byung Soh Min Yoon Jin Cha Ja Seung Koo Joon Jeong Jinu Lee Junjeong Choi Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
description	Abstract Adipocytes influence breast cancer behaviour via fatty acid release into the tumour microenvironment. Co-culturing human adipocytes and breast cancer cells increased CD36 expression, with fatty acid import into breast cancer cells. Genetic ablation of CD36 attenuates adipocyte-induced epithelial-mesenchymal transition (EMT) and stemness. We show a feedforward loop between CD36 and STAT3; where CD36 activates STAT3 signalling and STAT3 binds to the CD36 promoter, regulating its expression. CD36 expression results in metabolic reprogramming, with a shift towards fatty acid oxidation. CD36 inhibition induces de novo lipogenesis in breast cancer cells. Increased CD36 expression occurs with increased FABP4 expression. We showed that CD36 directly interacts with FABP4 to regulate fatty acid import, transport, and metabolism. CD36 and FABP4 inhibition induces apoptosis in tumour cells. These results indicate that CD36 mediates fatty acid import from adipocytes into cancer cells and activates signalling pathways that drive tumour progression. Targeting CD36 may have a potential for therapy, which will target the tumour microenvironment.
format	article
author	Jones Gyamfi Joo Hye Yeo Doru Kwon Byung Soh Min Yoon Jin Cha Ja Seung Koo Joon Jeong Jinu Lee Junjeong Choi
author_facet	Jones Gyamfi Joo Hye Yeo Doru Kwon Byung Soh Min Yoon Jin Cha Ja Seung Koo Joon Jeong Jinu Lee Junjeong Choi
author_sort	Jones Gyamfi
title	Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
title_short	Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
title_full	Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
title_fullStr	Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
title_full_unstemmed	Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
title_sort	interaction between cd36 and fabp4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a156fe2efe22458ca29d0ef7df1fc3eb
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Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer

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