Parasites and diet as main drivers of the Malagasy gut microbiome richness and function
Abstract Interactions between the prokaryotic microbiome and eukaryotic parasites in the vertebrate gut may affect overall host health and disease. While intertropical areas exhibit a high rate of parasites carriers, such interactions are understudied in these populations. Our objectives were to (1)...
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Nature Portfolio
2021
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oai:doaj.org-article:a157d40eb0624949a1cef9c23d55357c2021-12-02T17:51:21ZParasites and diet as main drivers of the Malagasy gut microbiome richness and function10.1038/s41598-021-96967-42045-2322https://doaj.org/article/a157d40eb0624949a1cef9c23d55357c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96967-4https://doaj.org/toc/2045-2322Abstract Interactions between the prokaryotic microbiome and eukaryotic parasites in the vertebrate gut may affect overall host health and disease. While intertropical areas exhibit a high rate of parasites carriers, such interactions are understudied in these populations. Our objectives were to (1) describe the gut microbiome of individuals living in Madagascar, (2) identify potential associations between bacterial taxa and parasites colonizing the digestive tract and (3) highlight main determinants of the gut microbiota composition in this developing country. Metadata (socioeconomic, diet, clinical) and fecal samples were collected from 219 volunteers from North-West Madagascar (Mahajanga). Fecal microbiome was assessed through 16S rRNA gene sequencing and metabolomics, and related to dietary habits and parasites carriage. We highlight important Malagasy gut microbiome peculiarities. Out of three detected enterotypes, only one is similar to that observed in Westernized countries (Ruminococcus-driven). Functions associated with the two others (Clostridium sensu stricto-driven and Escherichia/Shigella-driven) are mostly directed toward amino acids biosynthesis and degradation, respectively. Diet and protozoan carriage were the main drivers of microbiota composition. High protozoan carriage was associated with higher diversity, richness and microbial functionalities. The gut microbiome of Malagasy strongly differs from that of Westernized countries. Asymptomatic protozoan carriage and dietary habits are the external factors with the deepest impact on gut microbiome. Further studies are needed to understand whether gut microbial richness constitute a predilection niche for protozoans colonization, due to their gazing features, or whether the parasites themselves induce a higher bacterial richness.Stanislas MondotPhilippe PoirierAhmed Abou-BacarValentin GreigertJulie BrunetCéline NourrissonMilijaona RandrianarivelojosiaJean-Louis RazafindrakotoEugene MorelRivo S. RakotomalalaMarion LeclercKarine Le RouxCéline MonotPatricia LepageErmanno CandolfiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Stanislas Mondot Philippe Poirier Ahmed Abou-Bacar Valentin Greigert Julie Brunet Céline Nourrisson Milijaona Randrianarivelojosia Jean-Louis Razafindrakoto Eugene Morel Rivo S. Rakotomalala Marion Leclerc Karine Le Roux Céline Monot Patricia Lepage Ermanno Candolfi Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| description |
Abstract Interactions between the prokaryotic microbiome and eukaryotic parasites in the vertebrate gut may affect overall host health and disease. While intertropical areas exhibit a high rate of parasites carriers, such interactions are understudied in these populations. Our objectives were to (1) describe the gut microbiome of individuals living in Madagascar, (2) identify potential associations between bacterial taxa and parasites colonizing the digestive tract and (3) highlight main determinants of the gut microbiota composition in this developing country. Metadata (socioeconomic, diet, clinical) and fecal samples were collected from 219 volunteers from North-West Madagascar (Mahajanga). Fecal microbiome was assessed through 16S rRNA gene sequencing and metabolomics, and related to dietary habits and parasites carriage. We highlight important Malagasy gut microbiome peculiarities. Out of three detected enterotypes, only one is similar to that observed in Westernized countries (Ruminococcus-driven). Functions associated with the two others (Clostridium sensu stricto-driven and Escherichia/Shigella-driven) are mostly directed toward amino acids biosynthesis and degradation, respectively. Diet and protozoan carriage were the main drivers of microbiota composition. High protozoan carriage was associated with higher diversity, richness and microbial functionalities. The gut microbiome of Malagasy strongly differs from that of Westernized countries. Asymptomatic protozoan carriage and dietary habits are the external factors with the deepest impact on gut microbiome. Further studies are needed to understand whether gut microbial richness constitute a predilection niche for protozoans colonization, due to their gazing features, or whether the parasites themselves induce a higher bacterial richness. |
| format |
article |
| author |
Stanislas Mondot Philippe Poirier Ahmed Abou-Bacar Valentin Greigert Julie Brunet Céline Nourrisson Milijaona Randrianarivelojosia Jean-Louis Razafindrakoto Eugene Morel Rivo S. Rakotomalala Marion Leclerc Karine Le Roux Céline Monot Patricia Lepage Ermanno Candolfi |
| author_facet |
Stanislas Mondot Philippe Poirier Ahmed Abou-Bacar Valentin Greigert Julie Brunet Céline Nourrisson Milijaona Randrianarivelojosia Jean-Louis Razafindrakoto Eugene Morel Rivo S. Rakotomalala Marion Leclerc Karine Le Roux Céline Monot Patricia Lepage Ermanno Candolfi |
| author_sort |
Stanislas Mondot |
| title |
Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| title_short |
Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| title_full |
Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| title_fullStr |
Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| title_full_unstemmed |
Parasites and diet as main drivers of the Malagasy gut microbiome richness and function |
| title_sort |
parasites and diet as main drivers of the malagasy gut microbiome richness and function |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a157d40eb0624949a1cef9c23d55357c |
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