The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues

The vitamin D<sub>3</sub> structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D<sub>3</sub>. Many efforts have been made to date to as...

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Autores principales:	Fumihiro Kawagoe, Sayuri Mototani, Atsushi Kittaka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin D<sub>3</sub> synthesis D-ring modification structure-activity relationship Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a15807f742d24082a14ed00150e7ff8a
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spelling	oai:doaj.org-article:a15807f742d24082a14ed00150e7ff8a2021-11-25T16:53:15ZThe Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues10.3390/biom111116392218-273Xhttps://doaj.org/article/a15807f742d24082a14ed00150e7ff8a2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1639https://doaj.org/toc/2218-273XThe vitamin D<sub>3</sub> structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D<sub>3</sub>. Many efforts have been made to date to assess the possible clinical use of vitamin D. Some organic chemists focused on the D-ring structure of vitamin D and synthesized D-ring-modified vitamin D analogues, and their biological activities were studied. This review summarizes the synthetic methodologies of D-ring-modified vitamin D analogues, except for <i>seco</i>-D, and their preliminary biological profiles.Fumihiro KawagoeSayuri MototaniAtsushi KittakaMDPI AGarticlevitamin D<sub>3</sub>synthesisD-ring modificationstructure-activity relationshipMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1639, p 1639 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin D<sub>3</sub> synthesis D-ring modification structure-activity relationship Microbiology QR1-502
spellingShingle	vitamin D<sub>3</sub> synthesis D-ring modification structure-activity relationship Microbiology QR1-502 Fumihiro Kawagoe Sayuri Mototani Atsushi Kittaka The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
description	The vitamin D<sub>3</sub> structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D<sub>3</sub>. Many efforts have been made to date to assess the possible clinical use of vitamin D. Some organic chemists focused on the D-ring structure of vitamin D and synthesized D-ring-modified vitamin D analogues, and their biological activities were studied. This review summarizes the synthetic methodologies of D-ring-modified vitamin D analogues, except for <i>seco</i>-D, and their preliminary biological profiles.
format	article
author	Fumihiro Kawagoe Sayuri Mototani Atsushi Kittaka
author_facet	Fumihiro Kawagoe Sayuri Mototani Atsushi Kittaka
author_sort	Fumihiro Kawagoe
title	The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
title_short	The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
title_full	The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
title_fullStr	The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
title_full_unstemmed	The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues
title_sort	synthesis and biological evaluation of d-ring-modified vitamin d analogues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a15807f742d24082a14ed00150e7ff8a
work_keys_str_mv	AT fumihirokawagoe thesynthesisandbiologicalevaluationofdringmodifiedvitamindanalogues AT sayurimototani thesynthesisandbiologicalevaluationofdringmodifiedvitamindanalogues AT atsushikittaka thesynthesisandbiologicalevaluationofdringmodifiedvitamindanalogues AT fumihirokawagoe synthesisandbiologicalevaluationofdringmodifiedvitamindanalogues AT sayurimototani synthesisandbiologicalevaluationofdringmodifiedvitamindanalogues AT atsushikittaka synthesisandbiologicalevaluationofdringmodifiedvitamindanalogues
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The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues

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