Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy

Abstract High frequency ultrasonic imaging provides clinicians with high-resolution diagnostic images and more accurate measurement results. The technique is now widely used in ophthalmology, dermatology, and small animal imaging. However, since ultrasonic attenuation in tissue increases rapidly wit...

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Autores principales:	Xiaochun Wang, Jun Yang, Jianjun Ji, Yusheng Zhang, Sheng Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a159a9de4adc47e7a204659564d2e214
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spelling	oai:doaj.org-article:a159a9de4adc47e7a204659564d2e2142021-12-02T13:50:50ZResearch on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy10.1038/s41598-020-80406-x2045-2322https://doaj.org/article/a159a9de4adc47e7a204659564d2e2142021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80406-xhttps://doaj.org/toc/2045-2322Abstract High frequency ultrasonic imaging provides clinicians with high-resolution diagnostic images and more accurate measurement results. The technique is now widely used in ophthalmology, dermatology, and small animal imaging. However, since ultrasonic attenuation in tissue increases rapidly with increasing frequency, the depth of detection of high frequency ultrasound in tissue is limited to a few millimeters. In this paper, a novel method of using Golay-coded excitation as a replacement for conventional single-pulse excitation in high frequency ultrasound biomicroscopy was proposed, and real-time imaging was realized. While maintaining the transmission voltage and image resolution unchanged, the detection depth can be effectively improved. The ultrasonic transmission frequency is 30 MHz and the transmission voltage is ± 60 V p-p. In this study, 4-bit, 8-bit, and 16-bit coding sequences and decoding compression were used. To verify the effectiveness of the coding sequence in real-time imaging of ultrasound biomicroscopy, we designed a 10-μm diameter line target echo experiment, an ultrasound phantom experiment, and an in vitro porcine eye experiment. The experimental results show that the code/decode method of signal processing can not only maintain a resolution consistent with that of single-pulse transmission, but can also improve the detection depth and signal-to-noise ratio.Xiaochun WangJun YangJianjun JiYusheng ZhangSheng ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaochun Wang Jun Yang Jianjun Ji Yusheng Zhang Sheng Zhou Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
description	Abstract High frequency ultrasonic imaging provides clinicians with high-resolution diagnostic images and more accurate measurement results. The technique is now widely used in ophthalmology, dermatology, and small animal imaging. However, since ultrasonic attenuation in tissue increases rapidly with increasing frequency, the depth of detection of high frequency ultrasound in tissue is limited to a few millimeters. In this paper, a novel method of using Golay-coded excitation as a replacement for conventional single-pulse excitation in high frequency ultrasound biomicroscopy was proposed, and real-time imaging was realized. While maintaining the transmission voltage and image resolution unchanged, the detection depth can be effectively improved. The ultrasonic transmission frequency is 30 MHz and the transmission voltage is ± 60 V p-p. In this study, 4-bit, 8-bit, and 16-bit coding sequences and decoding compression were used. To verify the effectiveness of the coding sequence in real-time imaging of ultrasound biomicroscopy, we designed a 10-μm diameter line target echo experiment, an ultrasound phantom experiment, and an in vitro porcine eye experiment. The experimental results show that the code/decode method of signal processing can not only maintain a resolution consistent with that of single-pulse transmission, but can also improve the detection depth and signal-to-noise ratio.
format	article
author	Xiaochun Wang Jun Yang Jianjun Ji Yusheng Zhang Sheng Zhou
author_facet	Xiaochun Wang Jun Yang Jianjun Ji Yusheng Zhang Sheng Zhou
author_sort	Xiaochun Wang
title	Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
title_short	Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
title_full	Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
title_fullStr	Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
title_full_unstemmed	Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
title_sort	research on golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a159a9de4adc47e7a204659564d2e214
work_keys_str_mv	AT xiaochunwang researchongolaycodedexcitationinrealtimeimagingofhighfrequencyultrasoundbiomicroscopy AT junyang researchongolaycodedexcitationinrealtimeimagingofhighfrequencyultrasoundbiomicroscopy AT jianjunji researchongolaycodedexcitationinrealtimeimagingofhighfrequencyultrasoundbiomicroscopy AT yushengzhang researchongolaycodedexcitationinrealtimeimagingofhighfrequencyultrasoundbiomicroscopy AT shengzhou researchongolaycodedexcitationinrealtimeimagingofhighfrequencyultrasoundbiomicroscopy
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Research on Golay-coded excitation in real-time imaging of high frequency ultrasound biomicroscopy

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