Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study...

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Autores principales:	Enrique Almanza-Aguilera, Daniela Ceballos-Sánchez, David Achaintre, Joseph A Rothwell, Nasser Laouali, Gianluca Severi, Verena Katzke, Theron Johnson, Matthias B Schulze, Domenico Palli, Giuliana Gargano, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Augustin Scalbert, Raul Zamora-Ros
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	urine catechin epicatechin flavan-3-ols biomarkers intake Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/a15c633683a34509a6579c0680ab580f
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spelling	oai:doaj.org-article:a15c633683a34509a6579c0680ab580f2021-11-25T18:37:12ZUrinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study10.3390/nu131141572072-6643https://doaj.org/article/a15c633683a34509a6579c0680ab580f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4157https://doaj.org/toc/2072-6643This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman’s correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute <i>r</i><sub>partial</sub> = 0.13–0.54, <i>p</i> < 0.05; and habitual <i>r</i><sub>partial</sub> = 0.14–0.28, <i>p</i> < 0.01), proanthocyanidins (acute <i>r</i><sub>partial</sub> = 0.24–0.49, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.10–0.15, <i>p</i> < 0.05), theaflavins (acute <i>r</i><sub>partial</sub> = 0.22–0.31, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.20–0.26, <i>p</i> < 0.01), and total flavan-3-ols (acute <i>r</i><sub>partial</sub> = 0.40–0.48, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.23–0.33, <i>p</i> < 0.001). Similarly, urinary concentrations of flavan-3-ols were weakly correlated with both acute (<i>r</i><sub>partial</sub> = 0.12–0.30, <i>p</i> < 0.05) and habitual intake (<i>r</i><sub>partial</sub> = 0.10–0.27, <i>p</i> < 0.05) of apple and pear, stone fruits, berries, chocolate and chocolate products, cakes and pastries, tea, herbal tea, wine, red wine, and beer and cider. Moreover, all comparable correlations were stronger for urinary (-)-epicatechin than for (+)-catechin. In conclusion, our data support the use of urinary concentrations of (+)-catechin and (-)-epicatechin, especially as short-term nutritional biomarkers of dietary catechin, epicatechin and total flavan-3-ol monomers.Enrique Almanza-AguileraDaniela Ceballos-SánchezDavid AchaintreJoseph A RothwellNasser LaoualiGianluca SeveriVerena KatzkeTheron JohnsonMatthias B SchulzeDomenico PalliGiuliana GarganoMaria Santucci de MagistrisRosario TuminoCarlotta SacerdoteAugustin ScalbertRaul Zamora-RosMDPI AGarticleurinecatechinepicatechinflavan-3-olsbiomarkersintakeNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4157, p 4157 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urine catechin epicatechin flavan-3-ols biomarkers intake Nutrition. Foods and food supply TX341-641
spellingShingle	urine catechin epicatechin flavan-3-ols biomarkers intake Nutrition. Foods and food supply TX341-641 Enrique Almanza-Aguilera Daniela Ceballos-Sánchez David Achaintre Joseph A Rothwell Nasser Laouali Gianluca Severi Verena Katzke Theron Johnson Matthias B Schulze Domenico Palli Giuliana Gargano Maria Santucci de Magistris Rosario Tumino Carlotta Sacerdote Augustin Scalbert Raul Zamora-Ros Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
description	This study examines the correlation of acute and habitual dietary intake of flavan-3-ol monomers, proanthocyanidins, theaflavins, and their main food sources with the urinary concentrations of (+)-catechin and (-)-epicatechin in the European Prospective Investigation into Cancer and Nutrition study (EPIC). Participants (N = 419, men and women) provided 24-h urine samples and completed a 24-h dietary recall (24-HDR) on the same day. Acute and habitual dietary data were collected using a standardized 24-HDR software and a validated dietary questionnaire, respectively. Intake of flavan-3-ols was estimated using the Phenol-Explorer database. Concentrations of (+)-catechin and (-)-epicatechin in 24-h urine were analyzed using tandem mass spectrometry after enzymatic deconjugation. Simple and partial Spearman’s correlations showed that urinary concentrations of (+)-catechin, (-)-epicatechin and their sum were more strongly correlated with acute than with habitual intake of individual and total monomers (acute <i>r</i><sub>partial</sub> = 0.13–0.54, <i>p</i> < 0.05; and habitual <i>r</i><sub>partial</sub> = 0.14–0.28, <i>p</i> < 0.01), proanthocyanidins (acute <i>r</i><sub>partial</sub> = 0.24–0.49, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.10–0.15, <i>p</i> < 0.05), theaflavins (acute <i>r</i><sub>partial</sub> = 0.22–0.31, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.20–0.26, <i>p</i> < 0.01), and total flavan-3-ols (acute <i>r</i><sub>partial</sub> = 0.40–0.48, <i>p</i> < 0.001; and habitual <i>r</i><sub>partial</sub> = 0.23–0.33, <i>p</i> < 0.001). Similarly, urinary concentrations of flavan-3-ols were weakly correlated with both acute (<i>r</i><sub>partial</sub> = 0.12–0.30, <i>p</i> < 0.05) and habitual intake (<i>r</i><sub>partial</sub> = 0.10–0.27, <i>p</i> < 0.05) of apple and pear, stone fruits, berries, chocolate and chocolate products, cakes and pastries, tea, herbal tea, wine, red wine, and beer and cider. Moreover, all comparable correlations were stronger for urinary (-)-epicatechin than for (+)-catechin. In conclusion, our data support the use of urinary concentrations of (+)-catechin and (-)-epicatechin, especially as short-term nutritional biomarkers of dietary catechin, epicatechin and total flavan-3-ol monomers.
format	article
author	Enrique Almanza-Aguilera Daniela Ceballos-Sánchez David Achaintre Joseph A Rothwell Nasser Laouali Gianluca Severi Verena Katzke Theron Johnson Matthias B Schulze Domenico Palli Giuliana Gargano Maria Santucci de Magistris Rosario Tumino Carlotta Sacerdote Augustin Scalbert Raul Zamora-Ros
author_facet	Enrique Almanza-Aguilera Daniela Ceballos-Sánchez David Achaintre Joseph A Rothwell Nasser Laouali Gianluca Severi Verena Katzke Theron Johnson Matthias B Schulze Domenico Palli Giuliana Gargano Maria Santucci de Magistris Rosario Tumino Carlotta Sacerdote Augustin Scalbert Raul Zamora-Ros
author_sort	Enrique Almanza-Aguilera
title	Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_short	Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_full	Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_fullStr	Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_full_unstemmed	Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_sort	urinary concentrations of (+)-catechin and (-)-epicatechin as biomarkers of dietary intake of flavan-3-ols in the european prospective investigation into cancer and nutrition (epic) study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a15c633683a34509a6579c0680ab580f
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Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

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