THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES

Objective: To evaluate the effect of Ficus carica on lead acetate induced changes in the height of germinal epithelium of seminiferous tubules in testes of adult rats. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted for a period of 8 weeks at Dep...

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Autores principales:	Ayesha Asad, Afnan Gul, Maria Yousaf, Khadija Qamar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	ficus carica germinal epithelium Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a15f7b2a7c1740aeb0606e372f49794f
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spelling	oai:doaj.org-article:a15f7b2a7c1740aeb0606e372f49794f2021-11-12T07:09:44ZTHE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES0030-96482411-8842https://doaj.org/article/a15f7b2a7c1740aeb0606e372f49794f2019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2759/2164https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the effect of Ficus carica on lead acetate induced changes in the height of germinal epithelium of seminiferous tubules in testes of adult rats. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted for a period of 8 weeks at Departments of Anatomy and Pathology, Army Medical College, Rawalpindi in collaboration with National Institute of Health (NIH), Islamabad Pakistan. Material and Methods: Thirty healthy adult male Sprague-dawley rats were selected by simple random sampling and divided into three groups. Each group consisted of 10 animals. Group A served as control. Group B was given lead acetate 30 mg/kg body weight/day. Group C received Ficus carica 80 mg/kg bodyweight/day in addition to lead acetate 30 mg/kg bodyweight/ day. The dose was administered once a day for a period of 8 weeks. Twenty-four hours after administration of last dose, the animals were sacrificed and testes were removed. Testicular tissue was processed and stained with haematoxylin and eosin. Height of germinal epithelium of the seminiferous tubules was measured. The data was analyzed using SPSS version 22. Results were considered significant at p-value<0.05. Results: In experimental group B, significant decrease in height of germinal epithelium was observed as compared to the control group of the germinal epithelium. In experimental group C, the height increased as compared to experimental group B. Conclusion: Our study proposes that the laboratory induced deleterious effects of lead acetate in the testes of adult rats may be limited by administering concomitant supplement of Ficus carica in adult rats.Ayesha AsadAfnan GulMaria YousafKhadija QamarArmy Medical College Rawalpindiarticleficus caricagerminal epitheliumMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 378-382 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ficus carica germinal epithelium Medicine R Medicine (General) R5-920
spellingShingle	ficus carica germinal epithelium Medicine R Medicine (General) R5-920 Ayesha Asad Afnan Gul Maria Yousaf Khadija Qamar THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
description	Objective: To evaluate the effect of Ficus carica on lead acetate induced changes in the height of germinal epithelium of seminiferous tubules in testes of adult rats. Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted for a period of 8 weeks at Departments of Anatomy and Pathology, Army Medical College, Rawalpindi in collaboration with National Institute of Health (NIH), Islamabad Pakistan. Material and Methods: Thirty healthy adult male Sprague-dawley rats were selected by simple random sampling and divided into three groups. Each group consisted of 10 animals. Group A served as control. Group B was given lead acetate 30 mg/kg body weight/day. Group C received Ficus carica 80 mg/kg bodyweight/day in addition to lead acetate 30 mg/kg bodyweight/ day. The dose was administered once a day for a period of 8 weeks. Twenty-four hours after administration of last dose, the animals were sacrificed and testes were removed. Testicular tissue was processed and stained with haematoxylin and eosin. Height of germinal epithelium of the seminiferous tubules was measured. The data was analyzed using SPSS version 22. Results were considered significant at p-value<0.05. Results: In experimental group B, significant decrease in height of germinal epithelium was observed as compared to the control group of the germinal epithelium. In experimental group C, the height increased as compared to experimental group B. Conclusion: Our study proposes that the laboratory induced deleterious effects of lead acetate in the testes of adult rats may be limited by administering concomitant supplement of Ficus carica in adult rats.
format	article
author	Ayesha Asad Afnan Gul Maria Yousaf Khadija Qamar
author_facet	Ayesha Asad Afnan Gul Maria Yousaf Khadija Qamar
author_sort	Ayesha Asad
title	THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
title_short	THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
title_full	THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
title_fullStr	THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
title_full_unstemmed	THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES
title_sort	effect of ficus carica on lead acetate induced changes in the height of germinal epithelium of seminiferous tubules of adult rat testes
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/a15f7b2a7c1740aeb0606e372f49794f
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THE EFFECT OF FICUS CARICA ON LEAD ACETATE INDUCED CHANGES IN THE HEIGHT OF GERMINAL EPITHELIUM OF SEMINIFEROUS TUBULES OF ADULT RAT TESTES

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