Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1

Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key t...

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Autores principales: Hang Cheng, Rajaa Sebaa, Nikita Malholtra, Baptiste Lacoste, Ziyad El Hankouri, Alexia Kirby, Nigel C. Bennett, Barry van Jaarsveld, Daniel W. Hart, Glenn J. Tattersall, Mary-Ellen Harper, Matthew E. Pamenter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/a160ac2d7e3742ccace85151b74f2388
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spelling oai:doaj.org-article:a160ac2d7e3742ccace85151b74f23882021-11-28T12:34:07ZNaked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP110.1038/s41467-021-27170-22041-1723https://doaj.org/article/a160ac2d7e3742ccace85151b74f23882021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27170-2https://doaj.org/toc/2041-1723Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key thermogenic mitochondrial protein: UCP1.Hang ChengRajaa SebaaNikita MalholtraBaptiste LacosteZiyad El HankouriAlexia KirbyNigel C. BennettBarry van JaarsveldDaniel W. HartGlenn J. TattersallMary-Ellen HarperMatthew E. PamenterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hang Cheng
Rajaa Sebaa
Nikita Malholtra
Baptiste Lacoste
Ziyad El Hankouri
Alexia Kirby
Nigel C. Bennett
Barry van Jaarsveld
Daniel W. Hart
Glenn J. Tattersall
Mary-Ellen Harper
Matthew E. Pamenter
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
description Naked mole-rats are hypoxia-tolerant mammals, and during hypoxia their body temperature decreases via unknown mechanisms. Here the authors report that the hypoxia-induced body temperature decrease in naked mole rats occurs through decreased brown adipose tissue thermogenesis via decreases in a key thermogenic mitochondrial protein: UCP1.
format article
author Hang Cheng
Rajaa Sebaa
Nikita Malholtra
Baptiste Lacoste
Ziyad El Hankouri
Alexia Kirby
Nigel C. Bennett
Barry van Jaarsveld
Daniel W. Hart
Glenn J. Tattersall
Mary-Ellen Harper
Matthew E. Pamenter
author_facet Hang Cheng
Rajaa Sebaa
Nikita Malholtra
Baptiste Lacoste
Ziyad El Hankouri
Alexia Kirby
Nigel C. Bennett
Barry van Jaarsveld
Daniel W. Hart
Glenn J. Tattersall
Mary-Ellen Harper
Matthew E. Pamenter
author_sort Hang Cheng
title Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
title_short Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
title_full Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
title_fullStr Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
title_full_unstemmed Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
title_sort naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in ucp1
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a160ac2d7e3742ccace85151b74f2388
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