Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from LELs.

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Autores principales: Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu, Zhipu Luo, Li Yu, Andrew J. Brown, Hongyuan Yang, Jia-Wei Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a1618c1145e844619404ada3db80b3f4
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spelling oai:doaj.org-article:a1618c1145e844619404ada3db80b3f42021-12-02T15:35:29ZAllosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P210.1038/s41467-019-08791-02041-1723https://doaj.org/article/a1618c1145e844619404ada3db80b3f42019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08791-0https://doaj.org/toc/2041-1723Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from LELs.Jiangqing DongXiming DuHuan WangJue WangChang LuXiang ChenZhiwen ZhuZhipu LuoLi YuAndrew J. BrownHongyuan YangJia-Wei WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiangqing Dong
Ximing Du
Huan Wang
Jue Wang
Chang Lu
Xiang Chen
Zhiwen Zhu
Zhipu Luo
Li Yu
Andrew J. Brown
Hongyuan Yang
Jia-Wei Wu
Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
description Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from LELs.
format article
author Jiangqing Dong
Ximing Du
Huan Wang
Jue Wang
Chang Lu
Xiang Chen
Zhiwen Zhu
Zhipu Luo
Li Yu
Andrew J. Brown
Hongyuan Yang
Jia-Wei Wu
author_facet Jiangqing Dong
Ximing Du
Huan Wang
Jue Wang
Chang Lu
Xiang Chen
Zhiwen Zhu
Zhipu Luo
Li Yu
Andrew J. Brown
Hongyuan Yang
Jia-Wei Wu
author_sort Jiangqing Dong
title Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
title_short Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
title_full Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
title_fullStr Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
title_full_unstemmed Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2
title_sort allosteric enhancement of orp1-mediated cholesterol transport by pi(4,5)p2/pi(3,4)p2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a1618c1145e844619404ada3db80b3f4
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