Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy

Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epilep...

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Autores principales:	Thato Mary Mokhothu, Kazumasa Zen Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	seizures hippocampus biomarkers temporal lobe epilepsy latent period pathological oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a161978057634d739fbc102e4083dba6
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spelling	oai:doaj.org-article:a161978057634d739fbc102e4083dba62021-12-01T02:05:00ZCharacterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy1662-515310.3389/fnbeh.2021.785328https://doaj.org/article/a161978057634d739fbc102e4083dba62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.785328/fullhttps://doaj.org/toc/1662-5153Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epileptic seizures, and it is usually the focus of TLE. Researchers have identified hippocampal high-frequency oscillations (HFOs) as a salient feature in people with TLE and animal models of this disease, arising before or at the onset of the epileptic event. To a certain extent, these pathological HFOs have served as a marker and a potential target for seizure attenuation using electrical or optogenetic interventions. However, many questions remain about whether we can reliably distinguish pathological from non-pathological HFOs and whether they can tell us about the development of the disease. While this would be an arduous task to perform in humans, animal models of TLE provide an excellent opportunity to study the characteristics of HFOs in predicting how epilepsy evolves. This minireview will (1) summarize what we know about the oscillatory disruption in TLE, (2) summarize knowledge about oscillatory changes in the latent period and their role in predicting seizures, and (3) propose future studies essential to uncovering potential treatments based on early detection of pathological HFOs.Thato Mary MokhothuKazumasa Zen TanakaFrontiers Media S.A.articleseizureshippocampusbiomarkerstemporal lobe epilepsylatent periodpathological oscillationsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	seizures hippocampus biomarkers temporal lobe epilepsy latent period pathological oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	seizures hippocampus biomarkers temporal lobe epilepsy latent period pathological oscillations Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Thato Mary Mokhothu Kazumasa Zen Tanaka Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
description	Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epileptic seizures, and it is usually the focus of TLE. Researchers have identified hippocampal high-frequency oscillations (HFOs) as a salient feature in people with TLE and animal models of this disease, arising before or at the onset of the epileptic event. To a certain extent, these pathological HFOs have served as a marker and a potential target for seizure attenuation using electrical or optogenetic interventions. However, many questions remain about whether we can reliably distinguish pathological from non-pathological HFOs and whether they can tell us about the development of the disease. While this would be an arduous task to perform in humans, animal models of TLE provide an excellent opportunity to study the characteristics of HFOs in predicting how epilepsy evolves. This minireview will (1) summarize what we know about the oscillatory disruption in TLE, (2) summarize knowledge about oscillatory changes in the latent period and their role in predicting seizures, and (3) propose future studies essential to uncovering potential treatments based on early detection of pathological HFOs.
format	article
author	Thato Mary Mokhothu Kazumasa Zen Tanaka
author_facet	Thato Mary Mokhothu Kazumasa Zen Tanaka
author_sort	Thato Mary Mokhothu
title	Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
title_short	Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
title_full	Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
title_fullStr	Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
title_full_unstemmed	Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
title_sort	characterizing hippocampal oscillatory signatures underlying seizures in temporal lobe epilepsy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a161978057634d739fbc102e4083dba6
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_version_	1718405919535005696

Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy

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