Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment

Abstract In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prev...

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Autores principales:	Yi-Heng Li, Wei-Kung Tseng, Wei-Hsian Yin, Fang-Ju Lin, Yen-Wen Wu, I-Chang Hsieh, Tsung-Hsien Lin, Wayne Huey-Herng Sheu, Hung-I Yeh, Jaw-Wen Chen, Chau-Chung Wu, Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a168825f796141f7b2334fc19a9e291a
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spelling	oai:doaj.org-article:a168825f796141f7b2334fc19a9e291a2021-12-02T13:34:11ZPrognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment10.1038/s41598-020-78828-82045-2322https://doaj.org/article/a168825f796141f7b2334fc19a9e291a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78828-8https://doaj.org/toc/2045-2322Abstract In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (T-SPARCLE) Registry, a multicenter, observational study of adult patients with ASCVD in Taiwan. Low HDL-C was defined as < 40 mg/dL for men and < 50 mg/dL for women. The primary outcome was a composite CV events including CV death, myocardial infarction (MI), stroke or cardiac arrest with resuscitation. A total of 3731 patients (mean age 65.6 years, 75.6% men) were included. Patients with on-treatment low HDL-C (44%, mean HDL-C 34.9 ± 6.8 mg/dL) were younger and with more diabetes and higher body weight. The mean follow-up time was 2.7 years. We used restricted cubic spline curves to examine the potential non-linear association between HDL-C and adverse outcomes. Decreased HDL-C levels were associated with a significantly increased risk of CV events in women (< 49 mg/dL in women) but not in men (< 42 mg/dL in men). However, the protective effect of elevated HDL-C levels was more prominent in men than in women. In ASCVD patients with statin therapy, low on-treatment HDL-C was common in Taiwan and associated with an increased risk of CV events in women. Higher HDL-C levels provided more protective effect in men than in women.Yi-Heng LiWei-Kung TsengWei-Hsian YinFang-Ju LinYen-Wen WuI-Chang HsiehTsung-Hsien LinWayne Huey-Herng SheuHung-I YehJaw-Wen ChenChau-Chung WuTaiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry InvestigatorsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Heng Li Wei-Kung Tseng Wei-Hsian Yin Fang-Ju Lin Yen-Wen Wu I-Chang Hsieh Tsung-Hsien Lin Wayne Huey-Herng Sheu Hung-I Yeh Jaw-Wen Chen Chau-Chung Wu Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
description	Abstract In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with AtheRosCLErotic disease (T-SPARCLE) Registry, a multicenter, observational study of adult patients with ASCVD in Taiwan. Low HDL-C was defined as < 40 mg/dL for men and < 50 mg/dL for women. The primary outcome was a composite CV events including CV death, myocardial infarction (MI), stroke or cardiac arrest with resuscitation. A total of 3731 patients (mean age 65.6 years, 75.6% men) were included. Patients with on-treatment low HDL-C (44%, mean HDL-C 34.9 ± 6.8 mg/dL) were younger and with more diabetes and higher body weight. The mean follow-up time was 2.7 years. We used restricted cubic spline curves to examine the potential non-linear association between HDL-C and adverse outcomes. Decreased HDL-C levels were associated with a significantly increased risk of CV events in women (< 49 mg/dL in women) but not in men (< 42 mg/dL in men). However, the protective effect of elevated HDL-C levels was more prominent in men than in women. In ASCVD patients with statin therapy, low on-treatment HDL-C was common in Taiwan and associated with an increased risk of CV events in women. Higher HDL-C levels provided more protective effect in men than in women.
format	article
author	Yi-Heng Li Wei-Kung Tseng Wei-Hsian Yin Fang-Ju Lin Yen-Wen Wu I-Chang Hsieh Tsung-Hsien Lin Wayne Huey-Herng Sheu Hung-I Yeh Jaw-Wen Chen Chau-Chung Wu Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators
author_facet	Yi-Heng Li Wei-Kung Tseng Wei-Hsian Yin Fang-Ju Lin Yen-Wen Wu I-Chang Hsieh Tsung-Hsien Lin Wayne Huey-Herng Sheu Hung-I Yeh Jaw-Wen Chen Chau-Chung Wu Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators
author_sort	Yi-Heng Li
title	Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
title_short	Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
title_full	Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
title_fullStr	Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
title_full_unstemmed	Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
title_sort	prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a168825f796141f7b2334fc19a9e291a
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Prognostic effect of high-density lipoprotein cholesterol level in patients with atherosclerotic cardiovascular disease under statin treatment

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