A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft

ABSTRACT Sometimes, to move ahead, you must take a look at where you have been. Culturing microbes is a foundational underpinning of microbiology. Before genome sequencing, researchers spent countless hours tediously deducing the nutritional requirements of bacterial isolates and tinkering with medi...

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Autor principal:	Paul Carini
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	cultivation functional genomics microbial metabolism microbial physiology uncultured microbes Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a169dd8be4d44ba3a957530b996e895d
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id	oai:doaj.org-article:a169dd8be4d44ba3a957530b996e895d
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spelling	oai:doaj.org-article:a169dd8be4d44ba3a957530b996e895d2021-12-02T18:25:17ZA “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft10.1128/mSystems.00092-192379-5077https://doaj.org/article/a169dd8be4d44ba3a957530b996e895d2019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00092-19https://doaj.org/toc/2379-5077ABSTRACT Sometimes, to move ahead, you must take a look at where you have been. Culturing microbes is a foundational underpinning of microbiology. Before genome sequencing, researchers spent countless hours tediously deducing the nutritional requirements of bacterial isolates and tinkering with medium formulations to entice new microbes into culture. This art of cultivation took a back seat to the powerful molecular tools of the last 25 years, and as a result, many researchers have forgotten the utility of having a culture in hand. This perception is changing, as there is clearly a renewed interest in isolating microbes from various environments. Here, I suggest three focus areas to ensure continued growth and success of this “cultural” renaissance, including (i) setting clear cultivation goals, (ii) funding exploratory cultivation, and (iii) culturing and studying unusual organisms. “Unculturable” is a frame of mind, not a state of microbiology; it is time to dust off the bottle of yeast extract.Paul CariniAmerican Society for Microbiologyarticlecultivationfunctional genomicsmicrobial metabolismmicrobial physiologyuncultured microbesMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cultivation functional genomics microbial metabolism microbial physiology uncultured microbes Microbiology QR1-502
spellingShingle	cultivation functional genomics microbial metabolism microbial physiology uncultured microbes Microbiology QR1-502 Paul Carini A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
description	ABSTRACT Sometimes, to move ahead, you must take a look at where you have been. Culturing microbes is a foundational underpinning of microbiology. Before genome sequencing, researchers spent countless hours tediously deducing the nutritional requirements of bacterial isolates and tinkering with medium formulations to entice new microbes into culture. This art of cultivation took a back seat to the powerful molecular tools of the last 25 years, and as a result, many researchers have forgotten the utility of having a culture in hand. This perception is changing, as there is clearly a renewed interest in isolating microbes from various environments. Here, I suggest three focus areas to ensure continued growth and success of this “cultural” renaissance, including (i) setting clear cultivation goals, (ii) funding exploratory cultivation, and (iii) culturing and studying unusual organisms. “Unculturable” is a frame of mind, not a state of microbiology; it is time to dust off the bottle of yeast extract.
format	article
author	Paul Carini
author_facet	Paul Carini
author_sort	Paul Carini
title	A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
title_short	A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
title_full	A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
title_fullStr	A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
title_full_unstemmed	A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft
title_sort	“cultural” renaissance: genomics breathes new life into an old craft
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/a169dd8be4d44ba3a957530b996e895d
work_keys_str_mv	AT paulcarini aculturalrenaissancegenomicsbreathesnewlifeintoanoldcraft AT paulcarini culturalrenaissancegenomicsbreathesnewlifeintoanoldcraft
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A “Cultural” Renaissance: Genomics Breathes New Life into an Old Craft

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