Tendon and multiomics: advantages, advances, and opportunities

Abstract Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not completely understood. Improved understanding of the metabolic nuances that cause diverse outcomes in tendinopathies is required to so...

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Autores principales:	Paula Sarmiento, Dianne Little
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/a16b230722ad4488a0c41506b7d952cf
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spelling	oai:doaj.org-article:a16b230722ad4488a0c41506b7d952cf2021-12-02T17:17:42ZTendon and multiomics: advantages, advances, and opportunities10.1038/s41536-021-00168-62057-3995https://doaj.org/article/a16b230722ad4488a0c41506b7d952cf2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00168-6https://doaj.org/toc/2057-3995Abstract Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not completely understood. Improved understanding of the metabolic nuances that cause diverse outcomes in tendinopathies is required to solve these problems. ‘Omics methods are increasingly used to characterize phenotypes in tissues. Multiomics integrates ‘omic datasets to identify coherent relationships and provide insight into differences in molecular and metabolic pathways between anatomic locations, and disease stages. This work reviews the current literature pertaining to multiomics in tendon and the potential of these platforms to improve tendon regeneration. We assessed the literature and identified areas where ‘omics platforms contribute to the field: (1) Tendon biology where their hierarchical complexity and demographic factors are studied. (2) Tendon degeneration and healing, where comparisons across tendon pathologies are analyzed. (3) The in vitro engineered tendon phenotype, where we compare the engineered phenotype to relevant native tissues. (4) Finally, we review regenerative and therapeutic approaches. We identified gaps in current knowledge and opportunities for future study: (1) The need to increase the diversity of human subjects and cell sources. (2) Opportunities to improve understanding of tendon heterogeneity. (3) The need to use these improvements to inform new engineered and regenerative therapeutic approaches. (4) The need to increase understanding of the development of tendon pathology. Together, the expanding use of various ‘omics platforms and data analysis resulting from these platforms could substantially contribute to major advances in the tendon tissue engineering and regenerative medicine field.Paula SarmientoDianne LittleNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Paula Sarmiento Dianne Little Tendon and multiomics: advantages, advances, and opportunities
description	Abstract Tendons heal by fibrosis, which hinders function and increases re-injury risk. Yet the biology that leads to degeneration and regeneration of tendons is not completely understood. Improved understanding of the metabolic nuances that cause diverse outcomes in tendinopathies is required to solve these problems. ‘Omics methods are increasingly used to characterize phenotypes in tissues. Multiomics integrates ‘omic datasets to identify coherent relationships and provide insight into differences in molecular and metabolic pathways between anatomic locations, and disease stages. This work reviews the current literature pertaining to multiomics in tendon and the potential of these platforms to improve tendon regeneration. We assessed the literature and identified areas where ‘omics platforms contribute to the field: (1) Tendon biology where their hierarchical complexity and demographic factors are studied. (2) Tendon degeneration and healing, where comparisons across tendon pathologies are analyzed. (3) The in vitro engineered tendon phenotype, where we compare the engineered phenotype to relevant native tissues. (4) Finally, we review regenerative and therapeutic approaches. We identified gaps in current knowledge and opportunities for future study: (1) The need to increase the diversity of human subjects and cell sources. (2) Opportunities to improve understanding of tendon heterogeneity. (3) The need to use these improvements to inform new engineered and regenerative therapeutic approaches. (4) The need to increase understanding of the development of tendon pathology. Together, the expanding use of various ‘omics platforms and data analysis resulting from these platforms could substantially contribute to major advances in the tendon tissue engineering and regenerative medicine field.
format	article
author	Paula Sarmiento Dianne Little
author_facet	Paula Sarmiento Dianne Little
author_sort	Paula Sarmiento
title	Tendon and multiomics: advantages, advances, and opportunities
title_short	Tendon and multiomics: advantages, advances, and opportunities
title_full	Tendon and multiomics: advantages, advances, and opportunities
title_fullStr	Tendon and multiomics: advantages, advances, and opportunities
title_full_unstemmed	Tendon and multiomics: advantages, advances, and opportunities
title_sort	tendon and multiomics: advantages, advances, and opportunities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a16b230722ad4488a0c41506b7d952cf
work_keys_str_mv	AT paulasarmiento tendonandmultiomicsadvantagesadvancesandopportunities AT diannelittle tendonandmultiomicsadvantagesadvancesandopportunities
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Tendon and multiomics: advantages, advances, and opportunities

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