Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.

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Detalles Bibliográficos
Autores principales: Lina Sun, Amy V. Paschall, Dustin R. Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L. Wantuch, Javid Aceil, Jeremy A. Duke, Celia C. LaBranche, Michael Tiemeyer, Fikri Y. Avci
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/a16d1523b6c047d7bab89124b3ad15ed
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Descripción
Sumario:T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.

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