Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.

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Autores principales:	Lina Sun, Amy V. Paschall, Dustin R. Middleton, Mayumi Ishihara, Ahmet Ozdilek, Paeton L. Wantuch, Javid Aceil, Jeremy A. Duke, Celia C. LaBranche, Michael Tiemeyer, Fikri Y. Avci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a16d1523b6c047d7bab89124b3ad15ed
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spelling	oai:doaj.org-article:a16d1523b6c047d7bab89124b3ad15ed2021-12-02T16:51:13ZGlycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help10.1038/s41467-020-16319-02041-1723https://doaj.org/article/a16d1523b6c047d7bab89124b3ad15ed2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16319-0https://doaj.org/toc/2041-1723T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.Lina SunAmy V. PaschallDustin R. MiddletonMayumi IshiharaAhmet OzdilekPaeton L. WantuchJavid AceilJeremy A. DukeCelia C. LaBrancheMichael TiemeyerFikri Y. AvciNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lina Sun Amy V. Paschall Dustin R. Middleton Mayumi Ishihara Ahmet Ozdilek Paeton L. Wantuch Javid Aceil Jeremy A. Duke Celia C. LaBranche Michael Tiemeyer Fikri Y. Avci Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
description	T cells recognize peptide antigens presented in the context of MHC but can additionally recognize non-conventional ligands. Here the authors show T cells specific for a HIV-1 associated glycopeptide antigen presented by MHC class II help envelope (Env) trimer induced humoral immune responses.
format	article
author	Lina Sun Amy V. Paschall Dustin R. Middleton Mayumi Ishihara Ahmet Ozdilek Paeton L. Wantuch Javid Aceil Jeremy A. Duke Celia C. LaBranche Michael Tiemeyer Fikri Y. Avci
author_facet	Lina Sun Amy V. Paschall Dustin R. Middleton Mayumi Ishihara Ahmet Ozdilek Paeton L. Wantuch Javid Aceil Jeremy A. Duke Celia C. LaBranche Michael Tiemeyer Fikri Y. Avci
author_sort	Lina Sun
title	Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
title_short	Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
title_full	Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
title_fullStr	Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
title_full_unstemmed	Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
title_sort	glycopeptide epitope facilitates hiv-1 envelope specific humoral immune responses by eliciting t cell help
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a16d1523b6c047d7bab89124b3ad15ed
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Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help

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