Micropetrosis in hemodialysis patients

Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads...

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Autores principales:	Aiji Yajima, Ken Tsuchiya, David B. Burr, Taro Murata, Masaki Nakamura, Masaaki Inaba, Yoshihiro Tominaga, Tatsuhiko Tanizawa, Takashi Nakayama, Akemi Ito, Kosaku Nitta
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Micropetrosis Bone histomorphometry μCT Hemodialysis patients Fracture risk Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/a16ecd06ef7d4a57ae0fbc513e2b5733
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spelling	oai:doaj.org-article:a16ecd06ef7d4a57ae0fbc513e2b57332021-12-04T04:34:34ZMicropetrosis in hemodialysis patients2352-187210.1016/j.bonr.2021.101150https://doaj.org/article/a16ecd06ef7d4a57ae0fbc513e2b57332021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352187221004071https://doaj.org/toc/2352-1872Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads to increased bone fragility. However, micropetrosis of hemodialysis (HD) patients has not been discussed at all. Micropetrosis area per bone area (Mp.Ar/B·Ar) and osteocyte number per micropetrosis area (Ot.N/Mp.Ar) were measured in nine HD patients with renal hyperparathyroidism (Group I), twelve patients with hypoparathyroidism within 1 year after the treatment of renal hyperparathyroidism (Group II) and seven patients suffering from hypoparathyroidism for over two years (Group III). And bone mineral density (BMD) and tissue mineral density (TMD) were calculated using μCT to evaluate bone mineral content of iliac bone of the patients. These parameters were compared among the three groups. Only Mp.Ar/B·Ar was statistically greater in Group II and III compared to Group I in the parameters of bone mineral content and micropetrosis. However, the other parameters were not statistically different among the three groups. In long-term HD patients, BMD and TMD may be modified by the causes of renal insufficiency and the treatment of renal bone disease. We concluded that Mp.Ar/B·Ar was greater in patients with long-term hypoparathyroidism than both those with short-term hypoparathyroidism and with renal hyperparathyroidism. Special attention should be paid to avoid long-term hypoparathyroidism of the patients from the view point of increased fracture risk caused by increased micropetrosis area.Aiji YajimaKen TsuchiyaDavid B. BurrTaro MurataMasaki NakamuraMasaaki InabaYoshihiro TominagaTatsuhiko TanizawaTakashi NakayamaAkemi ItoKosaku NittaElsevierarticleMicropetrosisBone histomorphometryμCTHemodialysis patientsFracture riskDiseases of the musculoskeletal systemRC925-935ENBone Reports, Vol 15, Iss , Pp 101150- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Micropetrosis Bone histomorphometry μCT Hemodialysis patients Fracture risk Diseases of the musculoskeletal system RC925-935
spellingShingle	Micropetrosis Bone histomorphometry μCT Hemodialysis patients Fracture risk Diseases of the musculoskeletal system RC925-935 Aiji Yajima Ken Tsuchiya David B. Burr Taro Murata Masaki Nakamura Masaaki Inaba Yoshihiro Tominaga Tatsuhiko Tanizawa Takashi Nakayama Akemi Ito Kosaku Nitta Micropetrosis in hemodialysis patients
description	Micropetrosis develops as a result of stagnation of calcium, phosphorus and bone fluid, which appears as highly mineralized bone area in the osteocytic perilacunar/canalicular system regardless of bone turnover of the patients. And microcracks are predisposed to increase in these areas, which leads to increased bone fragility. However, micropetrosis of hemodialysis (HD) patients has not been discussed at all. Micropetrosis area per bone area (Mp.Ar/B·Ar) and osteocyte number per micropetrosis area (Ot.N/Mp.Ar) were measured in nine HD patients with renal hyperparathyroidism (Group I), twelve patients with hypoparathyroidism within 1 year after the treatment of renal hyperparathyroidism (Group II) and seven patients suffering from hypoparathyroidism for over two years (Group III). And bone mineral density (BMD) and tissue mineral density (TMD) were calculated using μCT to evaluate bone mineral content of iliac bone of the patients. These parameters were compared among the three groups. Only Mp.Ar/B·Ar was statistically greater in Group II and III compared to Group I in the parameters of bone mineral content and micropetrosis. However, the other parameters were not statistically different among the three groups. In long-term HD patients, BMD and TMD may be modified by the causes of renal insufficiency and the treatment of renal bone disease. We concluded that Mp.Ar/B·Ar was greater in patients with long-term hypoparathyroidism than both those with short-term hypoparathyroidism and with renal hyperparathyroidism. Special attention should be paid to avoid long-term hypoparathyroidism of the patients from the view point of increased fracture risk caused by increased micropetrosis area.
format	article
author	Aiji Yajima Ken Tsuchiya David B. Burr Taro Murata Masaki Nakamura Masaaki Inaba Yoshihiro Tominaga Tatsuhiko Tanizawa Takashi Nakayama Akemi Ito Kosaku Nitta
author_facet	Aiji Yajima Ken Tsuchiya David B. Burr Taro Murata Masaki Nakamura Masaaki Inaba Yoshihiro Tominaga Tatsuhiko Tanizawa Takashi Nakayama Akemi Ito Kosaku Nitta
author_sort	Aiji Yajima
title	Micropetrosis in hemodialysis patients
title_short	Micropetrosis in hemodialysis patients
title_full	Micropetrosis in hemodialysis patients
title_fullStr	Micropetrosis in hemodialysis patients
title_full_unstemmed	Micropetrosis in hemodialysis patients
title_sort	micropetrosis in hemodialysis patients
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a16ecd06ef7d4a57ae0fbc513e2b5733
work_keys_str_mv	AT aijiyajima micropetrosisinhemodialysispatients AT kentsuchiya micropetrosisinhemodialysispatients AT davidbburr micropetrosisinhemodialysispatients AT taromurata micropetrosisinhemodialysispatients AT masakinakamura micropetrosisinhemodialysispatients AT masaakiinaba micropetrosisinhemodialysispatients AT yoshihirotominaga micropetrosisinhemodialysispatients AT tatsuhikotanizawa micropetrosisinhemodialysispatients AT takashinakayama micropetrosisinhemodialysispatients AT akemiito micropetrosisinhemodialysispatients AT kosakunitta micropetrosisinhemodialysispatients
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Micropetrosis in hemodialysis patients

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