Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin...

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Autores principales:	M. Welz, S. Eickhoff, Z. Abdullah, J. Trebicka, K. H. Gartlan, J. A. Spicer, A. J. Demetris, H. Akhlaghi, M. Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. A. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a16f075282c8487babc56ea336c15431
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spelling	oai:doaj.org-article:a16f075282c8487babc56ea336c154312021-12-02T15:34:14ZPerforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis10.1038/s41467-018-07213-x2041-1723https://doaj.org/article/a16f075282c8487babc56ea336c154312018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07213-xhttps://doaj.org/toc/2041-1723CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin inhibitors.M. WelzS. EickhoffZ. AbdullahJ. TrebickaK. H. GartlanJ. A. SpicerA. J. DemetrisH. AkhlaghiM. AntonK. ManskeD. ZehnB. NieswandtC. KurtsJ. A. TrapaniP. KnolleD. WohlleberW. KastenmüllerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Welz S. Eickhoff Z. Abdullah J. Trebicka K. H. Gartlan J. A. Spicer A. J. Demetris H. Akhlaghi M. Anton K. Manske D. Zehn B. Nieswandt C. Kurts J. A. Trapani P. Knolle D. Wohlleber W. Kastenmüller Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
description	CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin inhibitors.
format	article
author	M. Welz S. Eickhoff Z. Abdullah J. Trebicka K. H. Gartlan J. A. Spicer A. J. Demetris H. Akhlaghi M. Anton K. Manske D. Zehn B. Nieswandt C. Kurts J. A. Trapani P. Knolle D. Wohlleber W. Kastenmüller
author_facet	M. Welz S. Eickhoff Z. Abdullah J. Trebicka K. H. Gartlan J. A. Spicer A. J. Demetris H. Akhlaghi M. Anton K. Manske D. Zehn B. Nieswandt C. Kurts J. A. Trapani P. Knolle D. Wohlleber W. Kastenmüller
author_sort	M. Welz
title	Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
title_short	Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
title_full	Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
title_fullStr	Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
title_full_unstemmed	Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
title_sort	perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a16f075282c8487babc56ea336c15431
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Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

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