Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes
Abstract By interacting with the mRNA 5′ cap, the translation initiation factor eIF4E plays a critical role in selecting mRNAs for protein synthesis in eukaryotic cells. Caf20 is a member of the family of proteins found across eukaryotes termed 4E-BPs, which compete with eIF4G for interaction with e...
Enregistré dans:
Auteurs principaux: | Ebelechukwu C. Nwokoye, Eiman AlNaseem, Robert A. Crawford, Lydia M. Castelli, Martin D. Jennings, Christopher J. Kershaw, Graham D. Pavitt |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/a170f8d568954ea3bc06d0d1845d3a9b |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity
par: Christopher J. Kershaw, et autres
Publié: (2021) -
The structural basis of translational control by eIF2 phosphorylation
par: Tomas Adomavicius, et autres
Publié: (2019) -
A yeast purification system for human translation initiation factors eIF2 and eIF2Bε and their use in the diagnosis of CACH/VWM disease.
par: Rogerio A de Almeida, et autres
Publié: (2013) -
Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues
par: Eiman Elwakeel, et autres
Publié: (2021) -
Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
par: Jennifer E. Dawson, et autres
Publié: (2020)