Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs

Abstract Identification of a quantitative trait locus (QTL) related to a chronic respiratory disease such as Mycoplasmal pneumonia of swine (MPS) and immune-related traits is important for the genetic improvement of disease resistance in pigs. The objective of this study was to detect a novel QTL fo...

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Autores principales:	Yoshinobu Uemoto, Kasumi Ichinoseki, Toshimi Matsumoto, Nozomi Oka, Hironori Takamori, Hiroshi Kadowaki, Chihiro Kojima-Shibata, Eisaku Suzuki, Toshihiro Okamura, Hisashi Aso, Haruki Kitazawa, Masahiro Satoh, Hirohide Uenishi, Keiichi Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a175cde3990246b48aa2bef69561820d
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spelling	oai:doaj.org-article:a175cde3990246b48aa2bef69561820d2021-12-02T16:35:18ZGenome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs10.1038/s41598-021-95339-22045-2322https://doaj.org/article/a175cde3990246b48aa2bef69561820d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95339-2https://doaj.org/toc/2045-2322Abstract Identification of a quantitative trait locus (QTL) related to a chronic respiratory disease such as Mycoplasmal pneumonia of swine (MPS) and immune-related traits is important for the genetic improvement of disease resistance in pigs. The objective of this study was to detect a novel QTL for a total of 22 production, respiratory disease, and immune-related traits in Landrace pigs. A total of 874 Landrace purebred pigs, which were selected based on MPS resistance, were genotyped using the Illumina PorcineSNP60 BeadChip. We performed single nucleotide polymorphism (SNP)-based and haplotype-based genome-wide association studies (GWAS) to detect a novel QTL and to evaluate the possibility of a pleiotropic QTL for these traits. SNP-based GWAS detected a total of six significant regions in backfat thickness, ratio of granular leucocytes to lymphatic cells, plasma concentration of cortisol at different ages, and complement alternative pathway activity in serum. The significant region detected by haplotype-based GWAS was overlapped across the region detected by SNP-based GWAS. Most of these detected QTL regions were novel regions with some candidate genes located in them. With regard to a pleiotropic QTL among traits, only three of these detected QTL regions overlapped among traits, and many detected regions independently affected the traits.Yoshinobu UemotoKasumi IchinosekiToshimi MatsumotoNozomi OkaHironori TakamoriHiroshi KadowakiChihiro Kojima-ShibataEisaku SuzukiToshihiro OkamuraHisashi AsoHaruki KitazawaMasahiro SatohHirohide UenishiKeiichi SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshinobu Uemoto Kasumi Ichinoseki Toshimi Matsumoto Nozomi Oka Hironori Takamori Hiroshi Kadowaki Chihiro Kojima-Shibata Eisaku Suzuki Toshihiro Okamura Hisashi Aso Haruki Kitazawa Masahiro Satoh Hirohide Uenishi Keiichi Suzuki Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
description	Abstract Identification of a quantitative trait locus (QTL) related to a chronic respiratory disease such as Mycoplasmal pneumonia of swine (MPS) and immune-related traits is important for the genetic improvement of disease resistance in pigs. The objective of this study was to detect a novel QTL for a total of 22 production, respiratory disease, and immune-related traits in Landrace pigs. A total of 874 Landrace purebred pigs, which were selected based on MPS resistance, were genotyped using the Illumina PorcineSNP60 BeadChip. We performed single nucleotide polymorphism (SNP)-based and haplotype-based genome-wide association studies (GWAS) to detect a novel QTL and to evaluate the possibility of a pleiotropic QTL for these traits. SNP-based GWAS detected a total of six significant regions in backfat thickness, ratio of granular leucocytes to lymphatic cells, plasma concentration of cortisol at different ages, and complement alternative pathway activity in serum. The significant region detected by haplotype-based GWAS was overlapped across the region detected by SNP-based GWAS. Most of these detected QTL regions were novel regions with some candidate genes located in them. With regard to a pleiotropic QTL among traits, only three of these detected QTL regions overlapped among traits, and many detected regions independently affected the traits.
format	article
author	Yoshinobu Uemoto Kasumi Ichinoseki Toshimi Matsumoto Nozomi Oka Hironori Takamori Hiroshi Kadowaki Chihiro Kojima-Shibata Eisaku Suzuki Toshihiro Okamura Hisashi Aso Haruki Kitazawa Masahiro Satoh Hirohide Uenishi Keiichi Suzuki
author_facet	Yoshinobu Uemoto Kasumi Ichinoseki Toshimi Matsumoto Nozomi Oka Hironori Takamori Hiroshi Kadowaki Chihiro Kojima-Shibata Eisaku Suzuki Toshihiro Okamura Hisashi Aso Haruki Kitazawa Masahiro Satoh Hirohide Uenishi Keiichi Suzuki
author_sort	Yoshinobu Uemoto
title	Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
title_short	Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
title_full	Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
title_fullStr	Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
title_full_unstemmed	Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs
title_sort	genome-wide association studies for production, respiratory disease, and immune-related traits in landrace pigs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a175cde3990246b48aa2bef69561820d
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Genome-wide association studies for production, respiratory disease, and immune-related traits in Landrace pigs

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