Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present...

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Autores principales:	Ruisen Fu, Yili Feng, David Bertrand, Tianming Du, Youjun Liu, Bettina M. Willie, Haisheng Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	distraction osteogenesis rate-varying distraction finite element analysis mechano-regulatory tissue differentiation bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a177532304d448118a3e599a40164c33
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spelling	oai:doaj.org-article:a177532304d448118a3e599a40164c332021-11-11T17:11:26ZEnhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study10.3390/ijms2221117341422-00671661-6596https://doaj.org/article/a177532304d448118a3e599a40164c332021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11734https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.Ruisen FuYili FengDavid BertrandTianming DuYoujun LiuBettina M. WillieHaisheng YangMDPI AGarticledistraction osteogenesisrate-varying distractionfinite element analysismechano-regulatory tissue differentiationbone regenerationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11734, p 11734 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	distraction osteogenesis rate-varying distraction finite element analysis mechano-regulatory tissue differentiation bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	distraction osteogenesis rate-varying distraction finite element analysis mechano-regulatory tissue differentiation bone regeneration Biology (General) QH301-705.5 Chemistry QD1-999 Ruisen Fu Yili Feng David Bertrand Tianming Du Youjun Liu Bettina M. Willie Haisheng Yang Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
description	Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.
format	article
author	Ruisen Fu Yili Feng David Bertrand Tianming Du Youjun Liu Bettina M. Willie Haisheng Yang
author_facet	Ruisen Fu Yili Feng David Bertrand Tianming Du Youjun Liu Bettina M. Willie Haisheng Yang
author_sort	Ruisen Fu
title	Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_short	Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_full	Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_fullStr	Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_full_unstemmed	Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_sort	enhancing the efficiency of distraction osteogenesis through rate-varying distraction: a computational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a177532304d448118a3e599a40164c33
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Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

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