Obesity-related proteins score as a potential marker of breast cancer risk

Abstract There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-qu...

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Autores principales:	Sha Diao, Xueyao Wu, Xiaofan Zhang, Yu Hao, Bin Xu, Xu Li, Lulu Tian, Yunqi Miao, Xunying Zhao, Feng Ye, Jiayuan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a178f9a2b9c64d3eaf0cdfef76d29865
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spelling	oai:doaj.org-article:a178f9a2b9c64d3eaf0cdfef76d298652021-12-02T15:51:15ZObesity-related proteins score as a potential marker of breast cancer risk10.1038/s41598-021-87583-32045-2322https://doaj.org/article/a178f9a2b9c64d3eaf0cdfef76d298652021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87583-3https://doaj.org/toc/2045-2322Abstract There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case–control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS5pre or PS4post) was positively correlated with breast cancer risk (premenopausal: OR≤63 VS >63 3.696, 95% CI 2.025–6.747; postmenopausal: OR≤38 VS >38 7.100, 95% CI 3.134–16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.Sha DiaoXueyao WuXiaofan ZhangYu HaoBin XuXu LiLulu TianYunqi MiaoXunying ZhaoFeng YeJiayuan LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sha Diao Xueyao Wu Xiaofan Zhang Yu Hao Bin Xu Xu Li Lulu Tian Yunqi Miao Xunying Zhao Feng Ye Jiayuan Li Obesity-related proteins score as a potential marker of breast cancer risk
description	Abstract There is strong evidence to suggest that obesity-related proteins play a key role in pathways that are related to breast cancer. In this study, we aimed to establish a robust obesity-related protein score (ORPS) that could be used to assess breast cancer risk. Based on evidence from high-quality systematic reviews and population studies, we selected nine such proteins that are stable in vitro, and measured their circulating concentrations by ELISA in a case–control study conducted in Chengdu, Sichuan, China, with 279 breast cancer cases and 260 healthy controls. Two obesity-related protein scores (ORPS) were calculated using a three-step method, with linear-weighted summation, and the one with a larger area under the curve was chosen for further evaluation. As a result, ORPS (PS5pre or PS4post) was positively correlated with breast cancer risk (premenopausal: OR≤63 VS >63 3.696, 95% CI 2.025–6.747; postmenopausal: OR≤38 VS >38 7.100, 95% CI 3.134–16.084), and represented a better risk predictor among obese women compared to non-obese in pre- and postmenopausal women. Among different molecular subtypes, ORPS was positively correlated with Luminal breast cancer, with additionally positive association with triple-negative breast cancer in premenopausal women. The ORPS might be a potential marker of breast cancer risk among Chinese women.
format	article
author	Sha Diao Xueyao Wu Xiaofan Zhang Yu Hao Bin Xu Xu Li Lulu Tian Yunqi Miao Xunying Zhao Feng Ye Jiayuan Li
author_facet	Sha Diao Xueyao Wu Xiaofan Zhang Yu Hao Bin Xu Xu Li Lulu Tian Yunqi Miao Xunying Zhao Feng Ye Jiayuan Li
author_sort	Sha Diao
title	Obesity-related proteins score as a potential marker of breast cancer risk
title_short	Obesity-related proteins score as a potential marker of breast cancer risk
title_full	Obesity-related proteins score as a potential marker of breast cancer risk
title_fullStr	Obesity-related proteins score as a potential marker of breast cancer risk
title_full_unstemmed	Obesity-related proteins score as a potential marker of breast cancer risk
title_sort	obesity-related proteins score as a potential marker of breast cancer risk
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a178f9a2b9c64d3eaf0cdfef76d29865
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Obesity-related proteins score as a potential marker of breast cancer risk

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