Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The...

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Autores principales:	Muhammad Salem, Ahmed El‐Bardissy
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	lamotrigine leucopenia neutropenia phenytoin UGT1A4 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a1797e2df0754ec788314dee6a06a9fa
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spelling	oai:doaj.org-article:a1797e2df0754ec788314dee6a06a9fa2021-12-01T06:36:09ZLamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin2050-090410.1002/ccr3.5136https://doaj.org/article/a1797e2df0754ec788314dee6a06a9fa2021-11-01T00:00:00Zhttps://doi.org/10.1002/ccr3.5136https://doaj.org/toc/2050-0904Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.Muhammad SalemAhmed El‐BardissyWileyarticlelamotrigineleucopenianeutropeniaphenytoinUGT1A4MedicineRMedicine (General)R5-920ENClinical Case Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lamotrigine leucopenia neutropenia phenytoin UGT1A4 Medicine R Medicine (General) R5-920
spellingShingle	lamotrigine leucopenia neutropenia phenytoin UGT1A4 Medicine R Medicine (General) R5-920 Muhammad Salem Ahmed El‐Bardissy Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
description	Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.
format	article
author	Muhammad Salem Ahmed El‐Bardissy
author_facet	Muhammad Salem Ahmed El‐Bardissy
author_sort	Muhammad Salem
title	Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_short	Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_full	Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_fullStr	Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_full_unstemmed	Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
title_sort	lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a1797e2df0754ec788314dee6a06a9fa
work_keys_str_mv	AT muhammadsalem lamotrigineinducedneutropeniaafterhighdoseconcomitantinitiationwithphenytoin AT ahmedelbardissy lamotrigineinducedneutropeniaafterhighdoseconcomitantinitiationwithphenytoin
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Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

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