Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.

<h4>Background</h4>Reduced free thiols in plasma are indicative of oxidative stress, which is an important contributor to ischaemia-reperfusion injury (IRI) in kidney transplantation leading to kidney damage and possibly delayed graft function (DGF). In a post-hoc, exploratory analysis o...

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Autores principales:	Marie B Nielsen, Bente Jespersen, Henrik Birn, Nicoline V Krogstrup, Arno R Bourgonje, Henri G D Leuvenink, Harry van Goor, Rikke Nørregaard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a179e5b5247743adb26cb7044d9a5ceb
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spelling	oai:doaj.org-article:a179e5b5247743adb26cb7044d9a5ceb2021-12-02T20:18:20ZElevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.1932-620310.1371/journal.pone.0255930https://doaj.org/article/a179e5b5247743adb26cb7044d9a5ceb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255930https://doaj.org/toc/1932-6203<h4>Background</h4>Reduced free thiols in plasma are indicative of oxidative stress, which is an important contributor to ischaemia-reperfusion injury (IRI) in kidney transplantation leading to kidney damage and possibly delayed graft function (DGF). In a post-hoc, exploratory analysis of the randomised controlled CONTEXT trial, we investigated whether higher (i.e. less oxidised) plasma levels of free thiols as a biomarker of reduced oxidative stress are associated with a better initial graft function or a higher GFR.<h4>Methods</h4>Free thiol levels were measured in plasma at baseline, 30 and 90 minutes after reperfusion of the kidney as well as at Day 1, Day 5 and twelve months after kidney transplantation in 217 patients from the CONTEXT study. Free thiol levels were compared to the kidney graft function measured as the estimated time to a 50% reduction in plasma creatinine (tCr50), the risk of DGF and measured GFR (mGFR) at Day 5 and twelve months after transplantation.<h4>Results</h4>Higher levels of free thiols at Day 1 and Day 5 are associated with higher mGFR at Day 5 (p<0.001, r2adj. = 0.16; p<0.001, r2adj. = 0.25), as well as with mGFR at twelve months (p<0.001, r2adj. = 0.20; p<0.001, r2adj. = 0.16). However, plasma levels of free thiols at 30 minutes and 90 minutes, but not Day 1, were significantly higher among patients experiencing DGF.<h4>Conclusion</h4>Higher levels of plasma free thiols at Day 1 and Day 5, which are reflective of lower levels of oxidative stress, are associated with better early and late graft function in recipients of a kidney graft from deceased donors.<h4>Trial registration</h4>ClinicalTrials.gov Identifier: NCT01395719.Marie B NielsenBente JespersenHenrik BirnNicoline V KrogstrupArno R BourgonjeHenri G D LeuveninkHarry van GoorRikke NørregaardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255930 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie B Nielsen Bente Jespersen Henrik Birn Nicoline V Krogstrup Arno R Bourgonje Henri G D Leuvenink Harry van Goor Rikke Nørregaard Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
description	<h4>Background</h4>Reduced free thiols in plasma are indicative of oxidative stress, which is an important contributor to ischaemia-reperfusion injury (IRI) in kidney transplantation leading to kidney damage and possibly delayed graft function (DGF). In a post-hoc, exploratory analysis of the randomised controlled CONTEXT trial, we investigated whether higher (i.e. less oxidised) plasma levels of free thiols as a biomarker of reduced oxidative stress are associated with a better initial graft function or a higher GFR.<h4>Methods</h4>Free thiol levels were measured in plasma at baseline, 30 and 90 minutes after reperfusion of the kidney as well as at Day 1, Day 5 and twelve months after kidney transplantation in 217 patients from the CONTEXT study. Free thiol levels were compared to the kidney graft function measured as the estimated time to a 50% reduction in plasma creatinine (tCr50), the risk of DGF and measured GFR (mGFR) at Day 5 and twelve months after transplantation.<h4>Results</h4>Higher levels of free thiols at Day 1 and Day 5 are associated with higher mGFR at Day 5 (p<0.001, r2adj. = 0.16; p<0.001, r2adj. = 0.25), as well as with mGFR at twelve months (p<0.001, r2adj. = 0.20; p<0.001, r2adj. = 0.16). However, plasma levels of free thiols at 30 minutes and 90 minutes, but not Day 1, were significantly higher among patients experiencing DGF.<h4>Conclusion</h4>Higher levels of plasma free thiols at Day 1 and Day 5, which are reflective of lower levels of oxidative stress, are associated with better early and late graft function in recipients of a kidney graft from deceased donors.<h4>Trial registration</h4>ClinicalTrials.gov Identifier: NCT01395719.
format	article
author	Marie B Nielsen Bente Jespersen Henrik Birn Nicoline V Krogstrup Arno R Bourgonje Henri G D Leuvenink Harry van Goor Rikke Nørregaard
author_facet	Marie B Nielsen Bente Jespersen Henrik Birn Nicoline V Krogstrup Arno R Bourgonje Henri G D Leuvenink Harry van Goor Rikke Nørregaard
author_sort	Marie B Nielsen
title	Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
title_short	Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
title_full	Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
title_fullStr	Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
title_full_unstemmed	Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
title_sort	elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a179e5b5247743adb26cb7044d9a5ceb
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Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.

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