Interleukin-6 role in head and neck squamous cell carcinoma progression

Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT an...

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Autores principales:	Moaz M. Choudhary, Thomas J. France, Theodoros N. Teknos, Pawan Kumar
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/a184d75e4f0540a2abc410cf4774de84
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spelling	oai:doaj.org-article:a184d75e4f0540a2abc410cf4774de842021-12-02T13:26:50ZInterleukin-6 role in head and neck squamous cell carcinoma progression2095-881110.1016/j.wjorl.2016.05.002https://doaj.org/article/a184d75e4f0540a2abc410cf4774de842016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S209588111630035Xhttps://doaj.org/toc/2095-8811Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients. Keywords: Head and neck squamous cell carcinoma, Interleukin-6, JAK, STAT3, MAPK, PI3K/Akt, NanogMoaz M. ChoudharyThomas J. FranceTheodoros N. TeknosPawan KumarKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 90-97 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Moaz M. Choudhary Thomas J. France Theodoros N. Teknos Pawan Kumar Interleukin-6 role in head and neck squamous cell carcinoma progression
description	Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients. Keywords: Head and neck squamous cell carcinoma, Interleukin-6, JAK, STAT3, MAPK, PI3K/Akt, Nanog
format	article
author	Moaz M. Choudhary Thomas J. France Theodoros N. Teknos Pawan Kumar
author_facet	Moaz M. Choudhary Thomas J. France Theodoros N. Teknos Pawan Kumar
author_sort	Moaz M. Choudhary
title	Interleukin-6 role in head and neck squamous cell carcinoma progression
title_short	Interleukin-6 role in head and neck squamous cell carcinoma progression
title_full	Interleukin-6 role in head and neck squamous cell carcinoma progression
title_fullStr	Interleukin-6 role in head and neck squamous cell carcinoma progression
title_full_unstemmed	Interleukin-6 role in head and neck squamous cell carcinoma progression
title_sort	interleukin-6 role in head and neck squamous cell carcinoma progression
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/a184d75e4f0540a2abc410cf4774de84
work_keys_str_mv	AT moazmchoudhary interleukin6roleinheadandnecksquamouscellcarcinomaprogression AT thomasjfrance interleukin6roleinheadandnecksquamouscellcarcinomaprogression AT theodorosnteknos interleukin6roleinheadandnecksquamouscellcarcinomaprogression AT pawankumar interleukin6roleinheadandnecksquamouscellcarcinomaprogression
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Interleukin-6 role in head and neck squamous cell carcinoma progression

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