PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway

PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway

<b>Background</b>: Oral squamous cell carcinoma (OSCC) has a high prevalence and predicted global mortality rate of 67.1%, necessitating better therapeutic strategies. Moreover, the recurrence and resistance of OSCC after chemo/radioresistance remains a major bottleneck for its effective...

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Main Authors: Shin Pai, Vijesh Kumar Yadav, Kuang-Tai Kuo, Narpati Wesa Pikatan, Chun-Shu Lin, Ming-Hsien Chien, Wei-Hwa Lee, Michael Hsiao, Shao-Chih Chiu, Chi-Tai Yeh, Jo-Ting Tsai
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
OSCC
PDK1
CD47
cancer stem cells
glycolysis
chemo/radioresistance
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/a1855a558c4e4773ac1ec6099f77d687
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https://doaj.org/article/a1855a558c4e4773ac1ec6099f77d687

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