Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

Periodontal disease is a risk factor for Alzheimer’s disease Alzheimer’s disease is a scourge of longevity that will drain enormous resources from health budgets in the future. Unfortunately, the pathogenesis of the disease remains an enigma and there is no adequate treatment or prophylaxis for the...

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Autores principales:	Naoyuki Ishida, Yuichi Ishihara, Kazuto Ishida, Hiroyuki Tada, Yoshiko Funaki-Kato, Makoto Hagiwara, Taslima Ferdous, Mohammad Abdullah, Akio Mitani, Makoto Michikawa, Kenji Matsushita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a1870cb7e96941c7bb4e38f7baeebe20
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spelling	oai:doaj.org-article:a1870cb7e96941c7bb4e38f7baeebe202021-12-02T14:18:31ZPeriodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice10.1038/s41514-017-0015-x2056-3973https://doaj.org/article/a1870cb7e96941c7bb4e38f7baeebe202017-11-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0015-xhttps://doaj.org/toc/2056-3973Periodontal disease is a risk factor for Alzheimer’s disease Alzheimer’s disease is a scourge of longevity that will drain enormous resources from health budgets in the future. Unfortunately, the pathogenesis of the disease remains an enigma and there is no adequate treatment or prophylaxis for the disease. One key priority is to examine the modifiable risk factors that influence the development of dementia. A risk factor relationship between periodontal pathogens/periodontal disease and AD exists. In Alzheimer’s model mice infected with Porphromonas gingivalis, a type of periodontopathic bacterium, cognitive function was reduced and deposition of amyloid β peptide was increased. Moreover, inflammatory cytokines and bacterial endotoxin were increased in the serum and brain. Neuroinflammation may be caused by an increase in these inflammatory mediators, and the pathology of Alzheimer’s disease may be exacerbated. Since periodontal infections are treatable, treatment of periodontal diseases during this period may be effective for delaying the onset or progression of AD.Naoyuki IshidaYuichi IshiharaKazuto IshidaHiroyuki TadaYoshiko Funaki-KatoMakoto HagiwaraTaslima FerdousMohammad AbdullahAkio MitaniMakoto MichikawaKenji MatsushitaNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Naoyuki Ishida Yuichi Ishihara Kazuto Ishida Hiroyuki Tada Yoshiko Funaki-Kato Makoto Hagiwara Taslima Ferdous Mohammad Abdullah Akio Mitani Makoto Michikawa Kenji Matsushita Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
description	Periodontal disease is a risk factor for Alzheimer’s disease Alzheimer’s disease is a scourge of longevity that will drain enormous resources from health budgets in the future. Unfortunately, the pathogenesis of the disease remains an enigma and there is no adequate treatment or prophylaxis for the disease. One key priority is to examine the modifiable risk factors that influence the development of dementia. A risk factor relationship between periodontal pathogens/periodontal disease and AD exists. In Alzheimer’s model mice infected with Porphromonas gingivalis, a type of periodontopathic bacterium, cognitive function was reduced and deposition of amyloid β peptide was increased. Moreover, inflammatory cytokines and bacterial endotoxin were increased in the serum and brain. Neuroinflammation may be caused by an increase in these inflammatory mediators, and the pathology of Alzheimer’s disease may be exacerbated. Since periodontal infections are treatable, treatment of periodontal diseases during this period may be effective for delaying the onset or progression of AD.
format	article
author	Naoyuki Ishida Yuichi Ishihara Kazuto Ishida Hiroyuki Tada Yoshiko Funaki-Kato Makoto Hagiwara Taslima Ferdous Mohammad Abdullah Akio Mitani Makoto Michikawa Kenji Matsushita
author_facet	Naoyuki Ishida Yuichi Ishihara Kazuto Ishida Hiroyuki Tada Yoshiko Funaki-Kato Makoto Hagiwara Taslima Ferdous Mohammad Abdullah Akio Mitani Makoto Michikawa Kenji Matsushita
author_sort	Naoyuki Ishida
title	Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
title_short	Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
title_full	Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
title_fullStr	Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
title_full_unstemmed	Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice
title_sort	periodontitis induced by bacterial infection exacerbates features of alzheimer’s disease in transgenic mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a1870cb7e96941c7bb4e38f7baeebe20
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Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice

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