Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea plants, and stems and many more natural commodities. They have a multitude of applications through their anti-inflammatory, anti-oxidative, anti-carcinogenic properties, along with the ability to assist in the st...

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Autores principales:	Priyanka Ramesh, Rahul Jagadeesan, Saravanan Sekaran, Anuradha Dhanasekaran, Selvaraj Vimalraj
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	flavonoids bone osteoblast bone remodelling osteoclast Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/a18b28278f0a48a1bfcbaafa7442a1f0
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spelling	oai:doaj.org-article:a18b28278f0a48a1bfcbaafa7442a1f02021-11-30T12:13:20ZFlavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling1664-239210.3389/fendo.2021.779638https://doaj.org/article/a18b28278f0a48a1bfcbaafa7442a1f02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.779638/fullhttps://doaj.org/toc/1664-2392Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea plants, and stems and many more natural commodities. They have a multitude of applications through their anti-inflammatory, anti-oxidative, anti-carcinogenic properties, along with the ability to assist in the stimulation of bone formation. Bone, a rigid connective body tissue made up of cells embedded in a mineralised matrix is maintained by an assemblage of pathways assisting osteoblastogenesis and osteoclastogenesis. These have a significant impact on a plethora of bone diseases. The homeostasis between osteoblast and osteoclast formation decides the integrity and structure of the bone. The flavonoids discussed here are quercetin, kaempferol, icariin, myricetin, naringin, daidzein, luteolin, genistein, hesperidin, apigenin and several other flavonoids. The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa β (NF-kβ), Wnt/β-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling. In addition, these polyphenols regulate angiogenesis, decrease the levels of inflammatory cytokines and play a crucial role in scavenging reactive oxygen species (ROS). Considering these important effects of flavonoids, they may be regarded as a promising agent in treating bone-related ailments in the future.Priyanka RameshRahul JagadeesanSaravanan SekaranAnuradha DhanasekaranSelvaraj VimalrajFrontiers Media S.A.articleflavonoidsboneosteoblastbone remodellingosteoclastDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids bone osteoblast bone remodelling osteoclast Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	flavonoids bone osteoblast bone remodelling osteoclast Diseases of the endocrine glands. Clinical endocrinology RC648-665 Priyanka Ramesh Rahul Jagadeesan Saravanan Sekaran Anuradha Dhanasekaran Selvaraj Vimalraj Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
description	Flavonoids are polyphenolic compounds spotted in various fruits, vegetables, barks, tea plants, and stems and many more natural commodities. They have a multitude of applications through their anti-inflammatory, anti-oxidative, anti-carcinogenic properties, along with the ability to assist in the stimulation of bone formation. Bone, a rigid connective body tissue made up of cells embedded in a mineralised matrix is maintained by an assemblage of pathways assisting osteoblastogenesis and osteoclastogenesis. These have a significant impact on a plethora of bone diseases. The homeostasis between osteoblast and osteoclast formation decides the integrity and structure of the bone. The flavonoids discussed here are quercetin, kaempferol, icariin, myricetin, naringin, daidzein, luteolin, genistein, hesperidin, apigenin and several other flavonoids. The effects these flavonoids have on the mitogen activated protein kinase (MAPK), nuclear factor kappa β (NF-kβ), Wnt/β-catenin and bone morphogenetic protein 2/SMAD (BMP2/SMAD) signalling pathways, and apoptotic pathways lead to impacts on bone remodelling. In addition, these polyphenols regulate angiogenesis, decrease the levels of inflammatory cytokines and play a crucial role in scavenging reactive oxygen species (ROS). Considering these important effects of flavonoids, they may be regarded as a promising agent in treating bone-related ailments in the future.
format	article
author	Priyanka Ramesh Rahul Jagadeesan Saravanan Sekaran Anuradha Dhanasekaran Selvaraj Vimalraj
author_facet	Priyanka Ramesh Rahul Jagadeesan Saravanan Sekaran Anuradha Dhanasekaran Selvaraj Vimalraj
author_sort	Priyanka Ramesh
title	Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
title_short	Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
title_full	Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
title_fullStr	Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
title_full_unstemmed	Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
title_sort	flavonoids: classification, function, and molecular mechanisms involved in bone remodelling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a18b28278f0a48a1bfcbaafa7442a1f0
work_keys_str_mv	AT priyankaramesh flavonoidsclassificationfunctionandmolecularmechanismsinvolvedinboneremodelling AT rahuljagadeesan flavonoidsclassificationfunctionandmolecularmechanismsinvolvedinboneremodelling AT saravanansekaran flavonoidsclassificationfunctionandmolecularmechanismsinvolvedinboneremodelling AT anuradhadhanasekaran flavonoidsclassificationfunctionandmolecularmechanismsinvolvedinboneremodelling AT selvarajvimalraj flavonoidsclassificationfunctionandmolecularmechanismsinvolvedinboneremodelling
_version_	1718406640254844928

Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling

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