Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction

Abstract The aim of this study was to investigate the relationship between coronary wedge pressure (CWP), measured as a marker of pre-procedural microvascular obstruction, and left ventricular remodelling in high-risk ST-segment elevation myocardial infarction (STEMI) patients. Pre-revascularization...

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Autores principales:	Mãdãlin Constantin Marc, Adrian Corneliu Iancu, Camelia Diana Ober, Cãlin Homorodean, Şerban Bãlãnescu, Adela Viviana Sitar, Sorana Bolboacã, Ioana Mihaela Dregoesc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a18c9d7db3af41fdaf99e5957f55a941
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spelling	oai:doaj.org-article:a18c9d7db3af41fdaf99e5957f55a9412021-12-02T15:09:02ZPre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction10.1038/s41598-018-20276-62045-2322https://doaj.org/article/a18c9d7db3af41fdaf99e5957f55a9412018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20276-6https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the relationship between coronary wedge pressure (CWP), measured as a marker of pre-procedural microvascular obstruction, and left ventricular remodelling in high-risk ST-segment elevation myocardial infarction (STEMI) patients. Pre-revascularization CWP was measured in 25 patients with high-risk anterior STEMI. Left ventricular volumes and ejection fraction were echocardiographically measured at discharge and at follow-up. A 20% increase in left ventricular volumes was used to define remodelling. Patients with CWP ≤ 38 mmHg were characterized by late ventricular remodelling. Patients with CWP > 38 mmHg developed a progressive remodelling process which was associated with a significant 60 months increase in left ventricular volumes (P = 0.01 for end-systolic volume and 0.03 for end-diastolic volume) and a significant decrease in left ventricular ejection fraction (P = 0.05). A significant increase in both left ventricular end-systolic (P = 0.009) and end-diastolic volume (P = 0.02) from baseline to 60 months follow-up was recorded in patients with extracted thrombus length ≥2 mm. Pre-revascularization elevated CWP was associated with increased left ventricular volumes and decreased ejection fraction at long-term follow-up. CWP was a predictor of severe left ventricular enlargement, besides extracted thrombus quantity.Mãdãlin Constantin MarcAdrian Corneliu IancuCamelia Diana OberCãlin HomorodeanŞerban BãlãnescuAdela Viviana SitarSorana BolboacãIoana Mihaela DregoescNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mãdãlin Constantin Marc Adrian Corneliu Iancu Camelia Diana Ober Cãlin Homorodean Şerban Bãlãnescu Adela Viviana Sitar Sorana Bolboacã Ioana Mihaela Dregoesc Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
description	Abstract The aim of this study was to investigate the relationship between coronary wedge pressure (CWP), measured as a marker of pre-procedural microvascular obstruction, and left ventricular remodelling in high-risk ST-segment elevation myocardial infarction (STEMI) patients. Pre-revascularization CWP was measured in 25 patients with high-risk anterior STEMI. Left ventricular volumes and ejection fraction were echocardiographically measured at discharge and at follow-up. A 20% increase in left ventricular volumes was used to define remodelling. Patients with CWP ≤ 38 mmHg were characterized by late ventricular remodelling. Patients with CWP > 38 mmHg developed a progressive remodelling process which was associated with a significant 60 months increase in left ventricular volumes (P = 0.01 for end-systolic volume and 0.03 for end-diastolic volume) and a significant decrease in left ventricular ejection fraction (P = 0.05). A significant increase in both left ventricular end-systolic (P = 0.009) and end-diastolic volume (P = 0.02) from baseline to 60 months follow-up was recorded in patients with extracted thrombus length ≥2 mm. Pre-revascularization elevated CWP was associated with increased left ventricular volumes and decreased ejection fraction at long-term follow-up. CWP was a predictor of severe left ventricular enlargement, besides extracted thrombus quantity.
format	article
author	Mãdãlin Constantin Marc Adrian Corneliu Iancu Camelia Diana Ober Cãlin Homorodean Şerban Bãlãnescu Adela Viviana Sitar Sorana Bolboacã Ioana Mihaela Dregoesc
author_facet	Mãdãlin Constantin Marc Adrian Corneliu Iancu Camelia Diana Ober Cãlin Homorodean Şerban Bãlãnescu Adela Viviana Sitar Sorana Bolboacã Ioana Mihaela Dregoesc
author_sort	Mãdãlin Constantin Marc
title	Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
title_short	Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
title_full	Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
title_fullStr	Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
title_full_unstemmed	Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction
title_sort	pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute st-segment elevation myocardial infarction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a18c9d7db3af41fdaf99e5957f55a941
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Pre-revascularization coronary wedge pressure as marker of adverse long-term left ventricular remodelling in patients with acute ST-segment elevation myocardial infarction

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