Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance

Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.

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Autores principales: Dominic J. Vita, Cole J. Meier, Kendal Broadie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f1
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spelling oai:doaj.org-article:a18de3774e6c4bdb84f0be67a61453f12021-12-02T14:03:40ZNeuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance10.1038/s41467-021-21429-42041-1723https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21429-4https://doaj.org/toc/2041-1723Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.Dominic J. VitaCole J. MeierKendal BroadieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dominic J. Vita
Cole J. Meier
Kendal Broadie
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
description Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.
format article
author Dominic J. Vita
Cole J. Meier
Kendal Broadie
author_facet Dominic J. Vita
Cole J. Meier
Kendal Broadie
author_sort Dominic J. Vita
title Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_short Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_full Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_fullStr Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_full_unstemmed Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_sort neuronal fragile x mental retardation protein activates glial insulin receptor mediated pdf-tri neuron developmental clearance
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f1
work_keys_str_mv AT dominicjvita neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance
AT colejmeier neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance
AT kendalbroadie neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance
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