Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance

Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.

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Autores principales:	Dominic J. Vita, Cole J. Meier, Kendal Broadie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f1
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spelling	oai:doaj.org-article:a18de3774e6c4bdb84f0be67a61453f12021-12-02T14:03:40ZNeuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance10.1038/s41467-021-21429-42041-1723https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21429-4https://doaj.org/toc/2041-1723Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.Dominic J. VitaCole J. MeierKendal BroadieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominic J. Vita Cole J. Meier Kendal Broadie Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
description	Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.
format	article
author	Dominic J. Vita Cole J. Meier Kendal Broadie
author_facet	Dominic J. Vita Cole J. Meier Kendal Broadie
author_sort	Dominic J. Vita
title	Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_short	Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_full	Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_fullStr	Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_full_unstemmed	Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
title_sort	neuronal fragile x mental retardation protein activates glial insulin receptor mediated pdf-tri neuron developmental clearance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f1
work_keys_str_mv	AT dominicjvita neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance AT colejmeier neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance AT kendalbroadie neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance
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Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance

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