Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance
Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.
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Nature Portfolio
2021
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oai:doaj.org-article:a18de3774e6c4bdb84f0be67a61453f12021-12-02T14:03:40ZNeuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance10.1038/s41467-021-21429-42041-1723https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21429-4https://doaj.org/toc/2041-1723Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila.Dominic J. VitaCole J. MeierKendal BroadieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Dominic J. Vita Cole J. Meier Kendal Broadie Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
description |
Glia are involved in remodelling of neural circuits during development. Here, the authors show that FMRP is required within neurons to activate glial insulin receptor to facilitate Draper- and Shrub-dependent neuronal clearance during neurodevelopment in Drosophila. |
format |
article |
author |
Dominic J. Vita Cole J. Meier Kendal Broadie |
author_facet |
Dominic J. Vita Cole J. Meier Kendal Broadie |
author_sort |
Dominic J. Vita |
title |
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
title_short |
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
title_full |
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
title_fullStr |
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
title_full_unstemmed |
Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance |
title_sort |
neuronal fragile x mental retardation protein activates glial insulin receptor mediated pdf-tri neuron developmental clearance |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/a18de3774e6c4bdb84f0be67a61453f1 |
work_keys_str_mv |
AT dominicjvita neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance AT colejmeier neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance AT kendalbroadie neuronalfragilexmentalretardationproteinactivatesglialinsulinreceptormediatedpdftrineurondevelopmentalclearance |
_version_ |
1718392098850340864 |