A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles

This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ova...

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Autores principales:	Fumei Gao, Yanbin Wang, Dan Wu, Min Fu, Qiuxiang Zhang, Yumeng Ren, Zexi Yang, Huan Shen, Hongjing Han
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	GnRH antagonist premature rise of LH IVF cumulative live-birth rate advanced aged patients Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/a18e674a24644d45bfb29c1f73557a94
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spelling	oai:doaj.org-article:a18e674a24644d45bfb29c1f73557a942021-12-03T09:12:29ZA Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles1664-239210.3389/fendo.2021.722655https://doaj.org/article/a18e674a24644d45bfb29c1f73557a942021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.722655/fullhttps://doaj.org/toc/1664-2392This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ovarian stimulation and finished a follow-up for 3 years. A premature rise in LH was defined as an LH level >10 IU/L or >50% rise from baseline during ovarian stimulation. The cumulative live birth rate was calculated as the number of women who achieved a live birth divided by the total number of women who had either delivered a baby or had used up all their embryos received from the first stimulated cycle. In the advanced patients (≥37 years), the cumulative live birth rate was reduced in patients with a premature rise of LH (β: 0.20; 95% CI: 0.05–0.88; p=0.03), compared to patients (≥37 years) without the premature LH rise. The incidence of premature LH rise is associated with decreased rates of cumulative live birth rate in patients of advanced age (≥37 years) and aggravated the reduced potential of embryos produced by the advanced age, not the number of embryos.Fumei GaoYanbin WangDan WuMin FuQiuxiang ZhangYumeng RenZexi YangHuan ShenHongjing HanFrontiers Media S.A.articleGnRH antagonistpremature rise of LHIVFcumulative live-birth rateadvanced aged patientsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GnRH antagonist premature rise of LH IVF cumulative live-birth rate advanced aged patients Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	GnRH antagonist premature rise of LH IVF cumulative live-birth rate advanced aged patients Diseases of the endocrine glands. Clinical endocrinology RC648-665 Fumei Gao Yanbin Wang Dan Wu Min Fu Qiuxiang Zhang Yumeng Ren Zexi Yang Huan Shen Hongjing Han A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
description	This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ovarian stimulation and finished a follow-up for 3 years. A premature rise in LH was defined as an LH level >10 IU/L or >50% rise from baseline during ovarian stimulation. The cumulative live birth rate was calculated as the number of women who achieved a live birth divided by the total number of women who had either delivered a baby or had used up all their embryos received from the first stimulated cycle. In the advanced patients (≥37 years), the cumulative live birth rate was reduced in patients with a premature rise of LH (β: 0.20; 95% CI: 0.05–0.88; p=0.03), compared to patients (≥37 years) without the premature LH rise. The incidence of premature LH rise is associated with decreased rates of cumulative live birth rate in patients of advanced age (≥37 years) and aggravated the reduced potential of embryos produced by the advanced age, not the number of embryos.
format	article
author	Fumei Gao Yanbin Wang Dan Wu Min Fu Qiuxiang Zhang Yumeng Ren Zexi Yang Huan Shen Hongjing Han
author_facet	Fumei Gao Yanbin Wang Dan Wu Min Fu Qiuxiang Zhang Yumeng Ren Zexi Yang Huan Shen Hongjing Han
author_sort	Fumei Gao
title	A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
title_short	A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
title_full	A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
title_fullStr	A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
title_full_unstemmed	A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles
title_sort	premature rise of luteinizing hormone is associated with a reduced cumulative live birth rate in patients ≥37 years old undergoing gnrh antagonist in vitro fertilization cycles
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a18e674a24644d45bfb29c1f73557a94
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A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients ≥37 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles

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