Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch

Morphogenesis of tissue sheets is well studied, but mechanisms that shape bulk tissues are unclear. Here, the authors show that mesenchymal cells intercalate in 3D to shape the mouse branchial arch, with cortical forces driving intercalations in a Wnt5a-, Yap/Taz- and Piezo1-dependent manner.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hirotaka Tao, Min Zhu, Kimberly Lau, Owen K. W. Whitley, Mohammad Samani, Xiao Xiao, Xiao Xiao Chen, Noah A. Hahn, Weifan Liu, Megan Valencia, Min Wu, Xian Wang, Kelli D. Fenelon, Clarissa C. Pasiliao, Di Hu, Jinchun Wu, Shoshana Spring, James Ferguson, Edith P. Karuna, R. Mark Henkelman, Alexander Dunn, Huaxiong Huang, Hsin-Yi Henry Ho, Radhika Atit, Sidhartha Goyal, Yu Sun, Sevan Hopyan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1919169bcc7429c80847ae4da278f58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a1919169bcc7429c80847ae4da278f58
record_format	dspace
spelling	oai:doaj.org-article:a1919169bcc7429c80847ae4da278f582021-12-02T17:32:40ZOscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch10.1038/s41467-019-09540-z2041-1723https://doaj.org/article/a1919169bcc7429c80847ae4da278f582019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09540-zhttps://doaj.org/toc/2041-1723Morphogenesis of tissue sheets is well studied, but mechanisms that shape bulk tissues are unclear. Here, the authors show that mesenchymal cells intercalate in 3D to shape the mouse branchial arch, with cortical forces driving intercalations in a Wnt5a-, Yap/Taz- and Piezo1-dependent manner.Hirotaka TaoMin ZhuKimberly LauOwen K. W. WhitleyMohammad SamaniXiao XiaoXiao Xiao ChenNoah A. HahnWeifan LiuMegan ValenciaMin WuXian WangKelli D. FenelonClarissa C. PasiliaoDi HuJinchun WuShoshana SpringJames FergusonEdith P. KarunaR. Mark HenkelmanAlexander DunnHuaxiong HuangHsin-Yi Henry HoRadhika AtitSidhartha GoyalYu SunSevan HopyanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hirotaka Tao Min Zhu Kimberly Lau Owen K. W. Whitley Mohammad Samani Xiao Xiao Xiao Xiao Chen Noah A. Hahn Weifan Liu Megan Valencia Min Wu Xian Wang Kelli D. Fenelon Clarissa C. Pasiliao Di Hu Jinchun Wu Shoshana Spring James Ferguson Edith P. Karuna R. Mark Henkelman Alexander Dunn Huaxiong Huang Hsin-Yi Henry Ho Radhika Atit Sidhartha Goyal Yu Sun Sevan Hopyan Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
description	Morphogenesis of tissue sheets is well studied, but mechanisms that shape bulk tissues are unclear. Here, the authors show that mesenchymal cells intercalate in 3D to shape the mouse branchial arch, with cortical forces driving intercalations in a Wnt5a-, Yap/Taz- and Piezo1-dependent manner.
format	article
author	Hirotaka Tao Min Zhu Kimberly Lau Owen K. W. Whitley Mohammad Samani Xiao Xiao Xiao Xiao Chen Noah A. Hahn Weifan Liu Megan Valencia Min Wu Xian Wang Kelli D. Fenelon Clarissa C. Pasiliao Di Hu Jinchun Wu Shoshana Spring James Ferguson Edith P. Karuna R. Mark Henkelman Alexander Dunn Huaxiong Huang Hsin-Yi Henry Ho Radhika Atit Sidhartha Goyal Yu Sun Sevan Hopyan
author_facet	Hirotaka Tao Min Zhu Kimberly Lau Owen K. W. Whitley Mohammad Samani Xiao Xiao Xiao Xiao Chen Noah A. Hahn Weifan Liu Megan Valencia Min Wu Xian Wang Kelli D. Fenelon Clarissa C. Pasiliao Di Hu Jinchun Wu Shoshana Spring James Ferguson Edith P. Karuna R. Mark Henkelman Alexander Dunn Huaxiong Huang Hsin-Yi Henry Ho Radhika Atit Sidhartha Goyal Yu Sun Sevan Hopyan
author_sort	Hirotaka Tao
title	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
title_short	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
title_full	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
title_fullStr	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
title_full_unstemmed	Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
title_sort	oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a1919169bcc7429c80847ae4da278f58
work_keys_str_mv	AT hirotakatao oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT minzhu oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT kimberlylau oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT owenkwwhitley oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT mohammadsamani oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT xiaoxiao oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT xiaoxiaochen oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT noahahahn oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT weifanliu oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT meganvalencia oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT minwu oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT xianwang oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT kellidfenelon oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT clarissacpasiliao oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT dihu oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT jinchunwu oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT shoshanaspring oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT jamesferguson oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT edithpkaruna oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT rmarkhenkelman oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT alexanderdunn oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT huaxionghuang oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT hsinyihenryho oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT radhikaatit oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT sidharthagoyal oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT yusun oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch AT sevanhopyan oscillatorycorticalforcespromotethreedimensionalcellintercalationsthatshapethemurinemandibulararch
_version_	1718380266465001472

Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch

Ejemplares similares