Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch

Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch

Morphogenesis of tissue sheets is well studied, but mechanisms that shape bulk tissues are unclear. Here, the authors show that mesenchymal cells intercalate in 3D to shape the mouse branchial arch, with cortical forces driving intercalations in a Wnt5a-, Yap/Taz- and Piezo1-dependent manner.

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Bibliographic Details
Main Authors: Hirotaka Tao, Min Zhu, Kimberly Lau, Owen K. W. Whitley, Mohammad Samani, Xiao Xiao, Xiao Xiao Chen, Noah A. Hahn, Weifan Liu, Megan Valencia, Min Wu, Xian Wang, Kelli D. Fenelon, Clarissa C. Pasiliao, Di Hu, Jinchun Wu, Shoshana Spring, James Ferguson, Edith P. Karuna, R. Mark Henkelman, Alexander Dunn, Huaxiong Huang, Hsin-Yi Henry Ho, Radhika Atit, Sidhartha Goyal, Yu Sun, Sevan Hopyan
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/a1919169bcc7429c80847ae4da278f58
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https://doaj.org/article/a1919169bcc7429c80847ae4da278f58

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