Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women

Abstract This study was performed to evaluate serum estradiol level in postmenopausal women using oral menopausal hormone therapy (MHT) with different doses and formulations of estrogens. A total of 344 postmenopausal women who received oral MHT was included in this cross-sectional study. Serum estr...

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Autores principales:	Soo-Min Kim, Sung Eun Kim, Dong-Yun Lee, DooSeok Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a192e9b6d1f343538e70bff2c604be8d
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spelling	oai:doaj.org-article:a192e9b6d1f343538e70bff2c604be8d2021-12-02T14:11:30ZSerum estradiol level according to dose and formulation of oral estrogens in postmenopausal women10.1038/s41598-021-81201-y2045-2322https://doaj.org/article/a192e9b6d1f343538e70bff2c604be8d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81201-yhttps://doaj.org/toc/2045-2322Abstract This study was performed to evaluate serum estradiol level in postmenopausal women using oral menopausal hormone therapy (MHT) with different doses and formulations of estrogens. A total of 344 postmenopausal women who received oral MHT was included in this cross-sectional study. Serum estradiol level was compared according to formulation (estradiol hemihydrate [EH] or valerate [EV], conjugated estrogen [CE]) and dose (estradiol 1 or 2 mg, CE 0.45 or 0.625 mg) of the estrogens. Mean age and years since menopause were 56.9 and 7.9 years, respectively. Mean duration of MHT was 27.4 months. Since serum estradiol levels were not significantly different at either dose, EH and EV at the same dose were combined for comparisons: estradiol 1 mg and 2 mg. The serum estradiol level with estradiol 2 mg (107.6 pg/mL) was significantly higher by 60% than with estradiol 1 mg (65.8 pg/mL) or CE 0.45 mg (60.1 pg/mL), and it was also significantly higher than with CE 0.625 mg (76.8 pg/mL). Our findings suggest that serum estradiol level is not directly proportional to estrogen dose. In terms of serum concentration, CE 0.45 mg is equivalent to estradiol 1 mg.Soo-Min KimSung Eun KimDong-Yun LeeDooSeok ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soo-Min Kim Sung Eun Kim Dong-Yun Lee DooSeok Choi Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
description	Abstract This study was performed to evaluate serum estradiol level in postmenopausal women using oral menopausal hormone therapy (MHT) with different doses and formulations of estrogens. A total of 344 postmenopausal women who received oral MHT was included in this cross-sectional study. Serum estradiol level was compared according to formulation (estradiol hemihydrate [EH] or valerate [EV], conjugated estrogen [CE]) and dose (estradiol 1 or 2 mg, CE 0.45 or 0.625 mg) of the estrogens. Mean age and years since menopause were 56.9 and 7.9 years, respectively. Mean duration of MHT was 27.4 months. Since serum estradiol levels were not significantly different at either dose, EH and EV at the same dose were combined for comparisons: estradiol 1 mg and 2 mg. The serum estradiol level with estradiol 2 mg (107.6 pg/mL) was significantly higher by 60% than with estradiol 1 mg (65.8 pg/mL) or CE 0.45 mg (60.1 pg/mL), and it was also significantly higher than with CE 0.625 mg (76.8 pg/mL). Our findings suggest that serum estradiol level is not directly proportional to estrogen dose. In terms of serum concentration, CE 0.45 mg is equivalent to estradiol 1 mg.
format	article
author	Soo-Min Kim Sung Eun Kim Dong-Yun Lee DooSeok Choi
author_facet	Soo-Min Kim Sung Eun Kim Dong-Yun Lee DooSeok Choi
author_sort	Soo-Min Kim
title	Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
title_short	Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
title_full	Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
title_fullStr	Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
title_full_unstemmed	Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
title_sort	serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a192e9b6d1f343538e70bff2c604be8d
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Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women

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