Possible activation of effector B cells during drug‐induced hypersensitivity syndrome

Abstract Although the development of autoimmune disorders is recognized in drug‐induced hypersensitivity syndrome (DIHS), the serial change of B‐cell activity has not been well‐addressed. Herein, the serum levels of IL‐6, IL‐10, B‐cell activating factor of the tumor necrosis factor family (BAFF), an...

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Autores principales:	Yutaka Matsumura, Rei Watanabe, Yasuko Niijima, Haruka Kawakita, Junichi Furuta, Yoshiyuki Nakamura, Yosuke Ishitsuka, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	APRIL B cells BAFF cytokines drug‐induced hypersensitivity syndrome Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a195633fec104f5995783ac11eb0bd5b
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spelling	oai:doaj.org-article:a195633fec104f5995783ac11eb0bd5b2021-12-02T09:08:29ZPossible activation of effector B cells during drug‐induced hypersensitivity syndrome2574-459310.1002/cia2.12191https://doaj.org/article/a195633fec104f5995783ac11eb0bd5b2021-12-01T00:00:00Zhttps://doi.org/10.1002/cia2.12191https://doaj.org/toc/2574-4593Abstract Although the development of autoimmune disorders is recognized in drug‐induced hypersensitivity syndrome (DIHS), the serial change of B‐cell activity has not been well‐addressed. Herein, the serum levels of IL‐6, IL‐10, B‐cell activating factor of the tumor necrosis factor family (BAFF), and a proliferation‐inducing ligand (APRIL) in three DIHS patients were tracked over time. While IL‐6 and IL‐10 tended to be elevated according to the disease activity, BAFF and APRIL increased during the improved phase. Our results imply that the continuous activation of B cells may be involved in the prolonged disease activity of DIHS and the development of autoimmune disorders.Yutaka MatsumuraRei WatanabeYasuko NiijimaHaruka KawakitaJunichi FurutaYoshiyuki NakamuraYosuke IshitsukaNaoko OkiyamaYasuhiro FujisawaManabu FujimotoWileyarticleAPRILB cellsBAFFcytokinesdrug‐induced hypersensitivity syndromeDermatologyRL1-803Immunologic diseases. AllergyRC581-607ENJournal of Cutaneous Immunology and Allergy, Vol 4, Iss 6, Pp 166-169 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	APRIL B cells BAFF cytokines drug‐induced hypersensitivity syndrome Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
spellingShingle	APRIL B cells BAFF cytokines drug‐induced hypersensitivity syndrome Dermatology RL1-803 Immunologic diseases. Allergy RC581-607 Yutaka Matsumura Rei Watanabe Yasuko Niijima Haruka Kawakita Junichi Furuta Yoshiyuki Nakamura Yosuke Ishitsuka Naoko Okiyama Yasuhiro Fujisawa Manabu Fujimoto Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
description	Abstract Although the development of autoimmune disorders is recognized in drug‐induced hypersensitivity syndrome (DIHS), the serial change of B‐cell activity has not been well‐addressed. Herein, the serum levels of IL‐6, IL‐10, B‐cell activating factor of the tumor necrosis factor family (BAFF), and a proliferation‐inducing ligand (APRIL) in three DIHS patients were tracked over time. While IL‐6 and IL‐10 tended to be elevated according to the disease activity, BAFF and APRIL increased during the improved phase. Our results imply that the continuous activation of B cells may be involved in the prolonged disease activity of DIHS and the development of autoimmune disorders.
format	article
author	Yutaka Matsumura Rei Watanabe Yasuko Niijima Haruka Kawakita Junichi Furuta Yoshiyuki Nakamura Yosuke Ishitsuka Naoko Okiyama Yasuhiro Fujisawa Manabu Fujimoto
author_facet	Yutaka Matsumura Rei Watanabe Yasuko Niijima Haruka Kawakita Junichi Furuta Yoshiyuki Nakamura Yosuke Ishitsuka Naoko Okiyama Yasuhiro Fujisawa Manabu Fujimoto
author_sort	Yutaka Matsumura
title	Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
title_short	Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
title_full	Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
title_fullStr	Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
title_full_unstemmed	Possible activation of effector B cells during drug‐induced hypersensitivity syndrome
title_sort	possible activation of effector b cells during drug‐induced hypersensitivity syndrome
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/a195633fec104f5995783ac11eb0bd5b
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Possible activation of effector B cells during drug‐induced hypersensitivity syndrome

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