Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section

Shi-Chao Luo,1 Kai-Ming Duan,1 Chao Fang,1,2 Dan-Yang Li,1 Shan-Shan Zheng,1 Si-Qi Yang,1 Shu-Ting Yang,1 Mi Yang,1 Liang-Bin Zhang,1 Sai-Ying Wang1 1Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of China; 2Postdoctoral...

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Autores principales:	Luo SC, Duan KM, Fang C, Li DY, Zheng SS, Yang SQ, Yang ST, Yang M, Zhang LB, Wang SY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sirt genetic variants postpartum depressive symptoms；epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a19f9c33bbca44e9ae8041a5c6f6365d
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spelling	oai:doaj.org-article:a19f9c33bbca44e9ae8041a5c6f6365d2021-12-02T12:01:06ZCorrelations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section1178-2021https://doaj.org/article/a19f9c33bbca44e9ae8041a5c6f6365d2020-12-01T00:00:00Zhttps://www.dovepress.com/correlations-between-sirt-genetic-polymorphisms-and-postpartum-depress-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shi-Chao Luo,1 Kai-Ming Duan,1 Chao Fang,1,2 Dan-Yang Li,1 Shan-Shan Zheng,1 Si-Qi Yang,1 Shu-Ting Yang,1 Mi Yang,1 Liang-Bin Zhang,1 Sai-Ying Wang1 1Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of China; 2Postdoctoral Research Workstation of Clinical Medicine, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of ChinaCorrespondence: Sai-Ying WangDepartment of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of ChinaTel +86 731 8861-8150Email 1771303488@qq.comObjective: To investigate the association of genetic polymorphisms of SIRT with postpartum depressive symptoms and analyze the risk factors for postpartum depressive symptoms in women following cesarean section.Methods: A total of 368 Chinese woman undergoing cesarean section were enrolled in this study. A cutoff of ≥ 10 for the Edinburgh Postnatal Depression Scale identified postpartum depressive symptoms. Genotypes of SIRT1, SIRT 2, and SIRT 6 were determined using Sequenom MassArray single-nucleotide polymorphism (SNP) analysis. We analyzed the contribution of genetic factors (SNPs, linkage disequilibrium, and haplotype) to postpartum depressive symptoms and performed logistic regression analysis to identify all potential risk factors for postpartum depressive symptoms and define interactions between genetic and environmental factors.Results: The incidence of postpartum depressive symptoms was 18.7% in this cohort. Univariate analysis suggested that SIRT2 polymorphism at rs2873703 (TT genotype) and rs4801933 ((TT genotype) and SIRT6 polymorphism at rs350846 (CC genotype) and rs107251 (TT genotype) were significantly correlated with the occurrence of postpartum depressive symptoms (p< 0.05). Linkage disequilibrium was identified between SIRT6 polymorphisms rs350846 and rs107251. Incidence of postpartum depressive symptoms in cesarean-section parturients with SIRT2 haplotype CCC was decreased (OR 0.407, 95% CI 0.191– 0.867; p=0.016). SIRT2 polymorphisms rs2873703 and rs4801933 were multiply collinear. Logistic regression analysis showed that SIRT2 polymorphism at rs2873703 (TT genotype) and rs4801933 (TT genotype), domestic violence, stress during pregnancy, and depressive prenatal mood were risk factors for postpartum depressive symptoms (p< 0.05).Conclusion: Pregnant women with SIRT2 genotypes rs2873703 TT and rs4801933 TT and experiencing domestic violence, stress during pregnancy, and prenatal depression are more likely to suffer from postpartum depressive symptoms.Keywords: SIRT, genetic variants, postpartum depressive symptoms, epigeneticsLuo SCDuan KMFang CLi DYZheng SSYang SQYang STYang MZhang LBWang SYDove Medical Pressarticlesirtgenetic variantspostpartum depressive symptoms；epigeneticsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 3225-3238 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sirt genetic variants postpartum depressive symptoms；epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	sirt genetic variants postpartum depressive symptoms；epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Luo SC Duan KM Fang C Li DY Zheng SS Yang SQ Yang ST Yang M Zhang LB Wang SY Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
description	Shi-Chao Luo,1 Kai-Ming Duan,1 Chao Fang,1,2 Dan-Yang Li,1 Shan-Shan Zheng,1 Si-Qi Yang,1 Shu-Ting Yang,1 Mi Yang,1 Liang-Bin Zhang,1 Sai-Ying Wang1 1Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of China; 2Postdoctoral Research Workstation of Clinical Medicine, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of ChinaCorrespondence: Sai-Ying WangDepartment of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of ChinaTel +86 731 8861-8150Email 1771303488@qq.comObjective: To investigate the association of genetic polymorphisms of SIRT with postpartum depressive symptoms and analyze the risk factors for postpartum depressive symptoms in women following cesarean section.Methods: A total of 368 Chinese woman undergoing cesarean section were enrolled in this study. A cutoff of ≥ 10 for the Edinburgh Postnatal Depression Scale identified postpartum depressive symptoms. Genotypes of SIRT1, SIRT 2, and SIRT 6 were determined using Sequenom MassArray single-nucleotide polymorphism (SNP) analysis. We analyzed the contribution of genetic factors (SNPs, linkage disequilibrium, and haplotype) to postpartum depressive symptoms and performed logistic regression analysis to identify all potential risk factors for postpartum depressive symptoms and define interactions between genetic and environmental factors.Results: The incidence of postpartum depressive symptoms was 18.7% in this cohort. Univariate analysis suggested that SIRT2 polymorphism at rs2873703 (TT genotype) and rs4801933 ((TT genotype) and SIRT6 polymorphism at rs350846 (CC genotype) and rs107251 (TT genotype) were significantly correlated with the occurrence of postpartum depressive symptoms (p< 0.05). Linkage disequilibrium was identified between SIRT6 polymorphisms rs350846 and rs107251. Incidence of postpartum depressive symptoms in cesarean-section parturients with SIRT2 haplotype CCC was decreased (OR 0.407, 95% CI 0.191– 0.867; p=0.016). SIRT2 polymorphisms rs2873703 and rs4801933 were multiply collinear. Logistic regression analysis showed that SIRT2 polymorphism at rs2873703 (TT genotype) and rs4801933 (TT genotype), domestic violence, stress during pregnancy, and depressive prenatal mood were risk factors for postpartum depressive symptoms (p< 0.05).Conclusion: Pregnant women with SIRT2 genotypes rs2873703 TT and rs4801933 TT and experiencing domestic violence, stress during pregnancy, and prenatal depression are more likely to suffer from postpartum depressive symptoms.Keywords: SIRT, genetic variants, postpartum depressive symptoms, epigenetics
format	article
author	Luo SC Duan KM Fang C Li DY Zheng SS Yang SQ Yang ST Yang M Zhang LB Wang SY
author_facet	Luo SC Duan KM Fang C Li DY Zheng SS Yang SQ Yang ST Yang M Zhang LB Wang SY
author_sort	Luo SC
title	Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
title_short	Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
title_full	Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
title_fullStr	Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
title_full_unstemmed	Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section
title_sort	correlations between sirt genetic polymorphisms and postpartum depressive symptoms in chinese parturients who had undergone cesarean section
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/a19f9c33bbca44e9ae8041a5c6f6365d
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Correlations Between SIRT Genetic Polymorphisms and Postpartum Depressive Symptoms in Chinese Parturients Who Had Undergone Cesarean Section

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