PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, ma...

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Autores principales: Virginia Giuliani, Meredith A. Miller, Chiu-Yi Liu, Stella R. Hartono, Caleb A. Class, Christopher A. Bristow, Erika Suzuki, Lionel A. Sanz, Guang Gao, Jason P. Gay, Ningping Feng, Johnathon L. Rose, Hideo Tomihara, Joseph R. Daniele, Michael D. Peoples, Jennifer P. Bardenhagen, Mary K. Geck Do, Qing E. Chang, Bhavatarini Vangamudi, Christopher Vellano, Haoqiang Ying, Angela K. Deem, Kim-Anh Do, Giannicola Genovese, Joseph R. Marszalek, Jeffrey J. Kovacs, Michael Kim, Jason B. Fleming, Ernesto Guccione, Andrea Viale, Anirban Maitra, M. Emilia Di Francesco, Timothy A. Yap, Philip Jones, Giulio Draetta, Alessandro Carugo, Frederic Chedin, Timothy P. Heffernan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a1a1a41f3dcc4a47a61b299fda338c49
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spelling oai:doaj.org-article:a1a1a41f3dcc4a47a61b299fda338c492021-12-02T18:47:04ZPRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma10.1038/s41467-021-24798-y2041-1723https://doaj.org/article/a1a1a41f3dcc4a47a61b299fda338c492021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24798-yhttps://doaj.org/toc/2041-1723Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.Virginia GiulianiMeredith A. MillerChiu-Yi LiuStella R. HartonoCaleb A. ClassChristopher A. BristowErika SuzukiLionel A. SanzGuang GaoJason P. GayNingping FengJohnathon L. RoseHideo TomiharaJoseph R. DanieleMichael D. PeoplesJennifer P. BardenhagenMary K. Geck DoQing E. ChangBhavatarini VangamudiChristopher VellanoHaoqiang YingAngela K. DeemKim-Anh DoGiannicola GenoveseJoseph R. MarszalekJeffrey J. KovacsMichael KimJason B. FlemingErnesto GuccioneAndrea VialeAnirban MaitraM. Emilia Di FrancescoTimothy A. YapPhilip JonesGiulio DraettaAlessandro CarugoFrederic ChedinTimothy P. HeffernanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Virginia Giuliani
Meredith A. Miller
Chiu-Yi Liu
Stella R. Hartono
Caleb A. Class
Christopher A. Bristow
Erika Suzuki
Lionel A. Sanz
Guang Gao
Jason P. Gay
Ningping Feng
Johnathon L. Rose
Hideo Tomihara
Joseph R. Daniele
Michael D. Peoples
Jennifer P. Bardenhagen
Mary K. Geck Do
Qing E. Chang
Bhavatarini Vangamudi
Christopher Vellano
Haoqiang Ying
Angela K. Deem
Kim-Anh Do
Giannicola Genovese
Joseph R. Marszalek
Jeffrey J. Kovacs
Michael Kim
Jason B. Fleming
Ernesto Guccione
Andrea Viale
Anirban Maitra
M. Emilia Di Francesco
Timothy A. Yap
Philip Jones
Giulio Draetta
Alessandro Carugo
Frederic Chedin
Timothy P. Heffernan
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
description Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.
format article
author Virginia Giuliani
Meredith A. Miller
Chiu-Yi Liu
Stella R. Hartono
Caleb A. Class
Christopher A. Bristow
Erika Suzuki
Lionel A. Sanz
Guang Gao
Jason P. Gay
Ningping Feng
Johnathon L. Rose
Hideo Tomihara
Joseph R. Daniele
Michael D. Peoples
Jennifer P. Bardenhagen
Mary K. Geck Do
Qing E. Chang
Bhavatarini Vangamudi
Christopher Vellano
Haoqiang Ying
Angela K. Deem
Kim-Anh Do
Giannicola Genovese
Joseph R. Marszalek
Jeffrey J. Kovacs
Michael Kim
Jason B. Fleming
Ernesto Guccione
Andrea Viale
Anirban Maitra
M. Emilia Di Francesco
Timothy A. Yap
Philip Jones
Giulio Draetta
Alessandro Carugo
Frederic Chedin
Timothy P. Heffernan
author_facet Virginia Giuliani
Meredith A. Miller
Chiu-Yi Liu
Stella R. Hartono
Caleb A. Class
Christopher A. Bristow
Erika Suzuki
Lionel A. Sanz
Guang Gao
Jason P. Gay
Ningping Feng
Johnathon L. Rose
Hideo Tomihara
Joseph R. Daniele
Michael D. Peoples
Jennifer P. Bardenhagen
Mary K. Geck Do
Qing E. Chang
Bhavatarini Vangamudi
Christopher Vellano
Haoqiang Ying
Angela K. Deem
Kim-Anh Do
Giannicola Genovese
Joseph R. Marszalek
Jeffrey J. Kovacs
Michael Kim
Jason B. Fleming
Ernesto Guccione
Andrea Viale
Anirban Maitra
M. Emilia Di Francesco
Timothy A. Yap
Philip Jones
Giulio Draetta
Alessandro Carugo
Frederic Chedin
Timothy P. Heffernan
author_sort Virginia Giuliani
title PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
title_short PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
title_full PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
title_fullStr PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
title_full_unstemmed PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma
title_sort prmt1-dependent regulation of rna metabolism and dna damage response sustains pancreatic ductal adenocarcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a1a1a41f3dcc4a47a61b299fda338c49
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