Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis

Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of malignancy in the world. DNA cytosine-5-methyltransferase 1 (DNMT1) play key roles in carcinogenesis and regulation of the immune micro-environment, but the gene expression and the role of DNMT1 in HNSCC is unkno...

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Autores principales:	Jili Cui, Lian Zheng, Yuanyuan Zhang, Miaomiao Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a1a1e6b334eb4ce5ac3981d84259539b
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spelling	oai:doaj.org-article:a1a1e6b334eb4ce5ac3981d84259539b2021-12-02T14:16:42ZBioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis10.1038/s41598-021-81971-52045-2322https://doaj.org/article/a1a1e6b334eb4ce5ac3981d84259539b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81971-5https://doaj.org/toc/2045-2322Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of malignancy in the world. DNA cytosine-5-methyltransferase 1 (DNMT1) play key roles in carcinogenesis and regulation of the immune micro-environment, but the gene expression and the role of DNMT1 in HNSCC is unknown. In this study, we utilized online tools and databases for pan-cancer and HNSCC analysis of DNMT1 expression and its association with clinical cancer characteristics. We also identified genes that positively and negatively correlated with DNMT1 expression and identified eight hub genes based on protein–protein interaction (PPI) network analysis. Enrichment analyses were performed to explore the biological functions related with of DNMT1. The Tumor Immune Estimation Resource (TIMER) database was performed to explore the relationship between DNMT1 expression and immune-cell infiltration. We demonstrated that DNMT1 gene expression was upregulated in HNSCC and associated with poor prognosis. Based on analysis of the eight hub genes, we determined that DNMT1 may be involved in cell cycle, proliferation and metabolic related pathways. We also found that significant difference of B cells infiltration based on TP 53 mutation. These findings suggest that DNMT1 related epigenetic alterations have close relationship with HNSCC progression, and DNMT1 could be a novel diagnostic biomarker and a promising therapeutic target for HNSCC.Jili CuiLian ZhengYuanyuan ZhangMiaomiao XueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jili Cui Lian Zheng Yuanyuan Zhang Miaomiao Xue Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
description	Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of malignancy in the world. DNA cytosine-5-methyltransferase 1 (DNMT1) play key roles in carcinogenesis and regulation of the immune micro-environment, but the gene expression and the role of DNMT1 in HNSCC is unknown. In this study, we utilized online tools and databases for pan-cancer and HNSCC analysis of DNMT1 expression and its association with clinical cancer characteristics. We also identified genes that positively and negatively correlated with DNMT1 expression and identified eight hub genes based on protein–protein interaction (PPI) network analysis. Enrichment analyses were performed to explore the biological functions related with of DNMT1. The Tumor Immune Estimation Resource (TIMER) database was performed to explore the relationship between DNMT1 expression and immune-cell infiltration. We demonstrated that DNMT1 gene expression was upregulated in HNSCC and associated with poor prognosis. Based on analysis of the eight hub genes, we determined that DNMT1 may be involved in cell cycle, proliferation and metabolic related pathways. We also found that significant difference of B cells infiltration based on TP 53 mutation. These findings suggest that DNMT1 related epigenetic alterations have close relationship with HNSCC progression, and DNMT1 could be a novel diagnostic biomarker and a promising therapeutic target for HNSCC.
format	article
author	Jili Cui Lian Zheng Yuanyuan Zhang Miaomiao Xue
author_facet	Jili Cui Lian Zheng Yuanyuan Zhang Miaomiao Xue
author_sort	Jili Cui
title	Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
title_short	Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
title_full	Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
title_fullStr	Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
title_full_unstemmed	Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis
title_sort	bioinformatics analysis of dnmt1 expression and its role in head and neck squamous cell carcinoma prognosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1a1e6b334eb4ce5ac3981d84259539b
work_keys_str_mv	AT jilicui bioinformaticsanalysisofdnmt1expressionanditsroleinheadandnecksquamouscellcarcinomaprognosis AT lianzheng bioinformaticsanalysisofdnmt1expressionanditsroleinheadandnecksquamouscellcarcinomaprognosis AT yuanyuanzhang bioinformaticsanalysisofdnmt1expressionanditsroleinheadandnecksquamouscellcarcinomaprognosis AT miaomiaoxue bioinformaticsanalysisofdnmt1expressionanditsroleinheadandnecksquamouscellcarcinomaprognosis
_version_	1718391683927769088

Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis

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