Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

Molecular heterogeneity of acute myeloid leukaemia (AML) across patients is a major challenge for prognosis and therapy. Here, the authors show that NPM1 mutated AML is a heterogeneous class, consisting of two subtypes which exhibit distinct molecular characteristics, differentiation state, patient...

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Autores principales:	Arvind Singh Mer, Emily M. Heath, Seyed Ali Madani Tonekaboni, Nergiz Dogan-Artun, Sisira Kadambat Nair, Alex Murison, Laura Garcia-Prat, Liran Shlush, Rose Hurren, Veronique Voisin, Gary D. Bader, Corey Nislow, Mattias Rantalainen, Soren Lehmann, Mark Gower, Cynthia J. Guidos, Mathieu Lupien, John E. Dick, Mark D. Minden, Aaron D. Schimmer, Benjamin Haibe-Kains
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
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spelling	oai:doaj.org-article:a1a1fb4ad66d4a54b1ec1c09785a25512021-12-02T10:52:48ZBiological and therapeutic implications of a unique subtype of NPM1 mutated AML10.1038/s41467-021-21233-02041-1723https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a25512021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21233-0https://doaj.org/toc/2041-1723Molecular heterogeneity of acute myeloid leukaemia (AML) across patients is a major challenge for prognosis and therapy. Here, the authors show that NPM1 mutated AML is a heterogeneous class, consisting of two subtypes which exhibit distinct molecular characteristics, differentiation state, patient survival and drug response.Arvind Singh MerEmily M. HeathSeyed Ali Madani TonekaboniNergiz Dogan-ArtunSisira Kadambat NairAlex MurisonLaura Garcia-PratLiran ShlushRose HurrenVeronique VoisinGary D. BaderCorey NislowMattias RantalainenSoren LehmannMark GowerCynthia J. GuidosMathieu LupienJohn E. DickMark D. MindenAaron D. SchimmerBenjamin Haibe-KainsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arvind Singh Mer Emily M. Heath Seyed Ali Madani Tonekaboni Nergiz Dogan-Artun Sisira Kadambat Nair Alex Murison Laura Garcia-Prat Liran Shlush Rose Hurren Veronique Voisin Gary D. Bader Corey Nislow Mattias Rantalainen Soren Lehmann Mark Gower Cynthia J. Guidos Mathieu Lupien John E. Dick Mark D. Minden Aaron D. Schimmer Benjamin Haibe-Kains Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
description	Molecular heterogeneity of acute myeloid leukaemia (AML) across patients is a major challenge for prognosis and therapy. Here, the authors show that NPM1 mutated AML is a heterogeneous class, consisting of two subtypes which exhibit distinct molecular characteristics, differentiation state, patient survival and drug response.
format	article
author	Arvind Singh Mer Emily M. Heath Seyed Ali Madani Tonekaboni Nergiz Dogan-Artun Sisira Kadambat Nair Alex Murison Laura Garcia-Prat Liran Shlush Rose Hurren Veronique Voisin Gary D. Bader Corey Nislow Mattias Rantalainen Soren Lehmann Mark Gower Cynthia J. Guidos Mathieu Lupien John E. Dick Mark D. Minden Aaron D. Schimmer Benjamin Haibe-Kains
author_facet	Arvind Singh Mer Emily M. Heath Seyed Ali Madani Tonekaboni Nergiz Dogan-Artun Sisira Kadambat Nair Alex Murison Laura Garcia-Prat Liran Shlush Rose Hurren Veronique Voisin Gary D. Bader Corey Nislow Mattias Rantalainen Soren Lehmann Mark Gower Cynthia J. Guidos Mathieu Lupien John E. Dick Mark D. Minden Aaron D. Schimmer Benjamin Haibe-Kains
author_sort	Arvind Singh Mer
title	Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
title_short	Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
title_full	Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
title_fullStr	Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
title_full_unstemmed	Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
title_sort	biological and therapeutic implications of a unique subtype of npm1 mutated aml
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a1a1fb4ad66d4a54b1ec1c09785a2551
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Biological and therapeutic implications of a unique subtype of NPM1 mutated AML

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