In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different...

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Autores principales:	Raja Mohamed Beema Shafreen, Selvaraj Alagu Lakshmi, Shunmugiah Karutha Pandian, Young-Mo Kim, Joseph Deutsch, Elena Katrich, Shela Gorinstein
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	beverages health properties antioxidant activities fibrinogen albumin rutin Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/a1a2c2c4fb83450fb9537c273a565d3e
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spelling	oai:doaj.org-article:a1a2c2c4fb83450fb9537c273a565d3e2021-11-11T18:38:29ZIn Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum10.3390/molecules262166861420-3049https://doaj.org/article/a1a2c2c4fb83450fb9537c273a565d3e2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6686https://doaj.org/toc/1420-3049Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.Raja Mohamed Beema ShafreenSelvaraj Alagu LakshmiShunmugiah Karutha PandianYoung-Mo KimJoseph DeutschElena KatrichShela GorinsteinMDPI AGarticlebeverageshealth propertiesantioxidant activitiesfibrinogenalbuminrutinOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6686, p 6686 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beverages health properties antioxidant activities fibrinogen albumin rutin Organic chemistry QD241-441
spellingShingle	beverages health properties antioxidant activities fibrinogen albumin rutin Organic chemistry QD241-441 Raja Mohamed Beema Shafreen Selvaraj Alagu Lakshmi Shunmugiah Karutha Pandian Young-Mo Kim Joseph Deutsch Elena Katrich Shela Gorinstein In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
description	Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.
format	article
author	Raja Mohamed Beema Shafreen Selvaraj Alagu Lakshmi Shunmugiah Karutha Pandian Young-Mo Kim Joseph Deutsch Elena Katrich Shela Gorinstein
author_facet	Raja Mohamed Beema Shafreen Selvaraj Alagu Lakshmi Shunmugiah Karutha Pandian Young-Mo Kim Joseph Deutsch Elena Katrich Shela Gorinstein
author_sort	Raja Mohamed Beema Shafreen
title	In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
title_short	In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
title_full	In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
title_fullStr	In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
title_full_unstemmed	In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum
title_sort	in vitro and in silico interaction studies with red wine polyphenols against different proteins from human serum
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a1a2c2c4fb83450fb9537c273a565d3e
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In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

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