DOCKING OF TYROSINASE CICLOARTANE INHIBITORS

Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity...

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Autores principales:	Pablo A. GUTIÉRREZ, Benjamín A. ROJANO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	docking tyrosinase cicloartane inhibitor. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/a1a4242e93b748af9e8e6735b0157d5e
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spelling	oai:doaj.org-article:a1a4242e93b748af9e8e6735b0157d5e2021-11-19T04:15:28ZDOCKING OF TYROSINASE CICLOARTANE INHIBITORS0121-40042145-2660https://doaj.org/article/a1a4242e93b748af9e8e6735b0157d5e2009-07-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/1937https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds. However, the mechanism of inhibition of these molecules is not well understood. This paper present the results of a docking study between Berenjenol and its derivatives on tyrosinase enzyme that provides a rational framework for understanding the activity of these compounds. According to this work, Berenjenol acts as a competitive inhibitor of tyrosinase through interactions with Ile42, Met43 Arg55, Trp184, Asn191, His194, Val195, Ala202, Met201 and Thr203. Pablo A. GUTIÉRREZBenjamín A. ROJANOUniversidad de Antioquiaarticledockingtyrosinasecicloartaneinhibitor.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	docking tyrosinase cicloartane inhibitor. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	docking tyrosinase cicloartane inhibitor. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Pablo A. GUTIÉRREZ Benjamín A. ROJANO DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
description	Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds. However, the mechanism of inhibition of these molecules is not well understood. This paper present the results of a docking study between Berenjenol and its derivatives on tyrosinase enzyme that provides a rational framework for understanding the activity of these compounds. According to this work, Berenjenol acts as a competitive inhibitor of tyrosinase through interactions with Ile42, Met43 Arg55, Trp184, Asn191, His194, Val195, Ala202, Met201 and Thr203.
format	article
author	Pablo A. GUTIÉRREZ Benjamín A. ROJANO
author_facet	Pablo A. GUTIÉRREZ Benjamín A. ROJANO
author_sort	Pablo A. GUTIÉRREZ
title	DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
title_short	DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
title_full	DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
title_fullStr	DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
title_full_unstemmed	DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
title_sort	docking of tyrosinase cicloartane inhibitors
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/a1a4242e93b748af9e8e6735b0157d5e
work_keys_str_mv	AT pabloagutierrez dockingoftyrosinasecicloartaneinhibitors AT benjaminarojano dockingoftyrosinasecicloartaneinhibitors
_version_	1718420464122986496

DOCKING OF TYROSINASE CICLOARTANE INHIBITORS

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